[Question #10046] Questions of Tests

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26 months ago
Dear doctors,

I hope you are doing well. 
About a month ago I did an full std panel HIV, Syphilis, Herpes IGG 1/2 and HEp C and came out negative.
My risk was unprotected oral sex for 20 min and 1 minute of unprotected sex (condom broke)
The test were done 8 weeks after possible exposure. No symptoms so far. I just have one questions regarding my test results. It says very lipemic sample
and the lab is not responsible for results, My question is. Does this type of fat in blood could affect the result?
For the antibodies of herpes and HIV? My doctor said that I am negative but now I am not sure because of this of the lopemic note? Should i test again?

thank you!








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H. Hunter Handsfield, MD
26 months ago
Welcome to the forum. Thank you for your confidence in our services.

Lipemia -- cloudy blood plasma due to elevated triglycerides, cholesterol, etc -- is known to interfere only with blood counts (especially hemoglobin level) and chemistry tests, such as those to evaluate liver and kidney function. It is not known to interfere with any other kinds of tests, including various antibodies and other tests used to check for infectious diseases, and the lab's warning about it really doesn't apply. They just have a boiler plate statement as a CYA legal strategy. You can be sure all the negative results of your comprehensive STD test panel are accurate and reliable. (It takes up to 12 weeks for HSV IgG testing to become positive, but this has nothing to do with lipemia.)

The exposure described was very low risk. In absence of symptoms, I would have advised that no testing was necessary. The risk was too low, and some of the tests not very accurate anyway (especially herpes IgG testing); and others are zero risk for the events described (hepatitis B and C, for example). In the future, I would advise avoiding such comprehensive STD test panels after any particular sexual exposure. With rare exceptions, the only recommended testing would be blood tests for HIV and syphilis and urine for gonorrhea and chlamydia (which you don't mention, but probably was included, right?). But in any case, your negative results were reliable regardless of the lipemia. You don't need repeat testing of any kind.

Lipemia usually is caused by high blood levels of triglycerides, usually because of a rich/fatty meal recently. However, sometimes triglycerides are continually elevated as a result of various blood lipid ("cholesterol") disorders, diabetes, obesity, etc. If would be smart to let our primary care provider know of this issue and discuss whether additional testing or other evaluation should be considered.

I hope these comments are helpful. Let me know if anything isn't clear.

HHH, MD
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26 months ago
Thanks for the quick and prompt reply Dr Handsfield.  
I also tested for Gono and Chlam aso negative. Just to make sure then, now its been over 3 months and since no symptoms you dont recommend testing again. STD wise?  you mean asking again regarding the high fat on the blood test correct?

Thanks so much for the service!



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H. Hunter Handsfield, MD
26 months ago
Yes, I mean only that you should make sure your doctor knows of your lipemic blood, then follow her advice about possible additional testing for things like cholesterol problems, diabetes, etc. There was minimal STD risk from the exposure described and you do not need additional STD testing.

Thanks for the thanks!
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