Hello...I will try and make quick. I had some high risk(non-protected) going back to mid 2009.  Since that time I got tested multiple times for all STD.  I started testing in 2010 which included HIV tests of 3 and 4th generation along with RNA and DNA tests, up until January of 2015.  All have been negative.  In the same breath I also tested for all other STDs.  Starting in 2010 and until 2015 I tested ALOT for HIV x 30, syphilis with the RPR x 12, TPPA x3 , TP- antibody(Trep-Sure)x 6 and FTA-ABS x 6.  Things were going great until back in January of '15 I tested again for peace of mind for all (HIV 4th gen, RPR, FTA-ABS, Tp-antibody.).  All was good execpt i got positive FTA.  I repeated it a week later, and month later, and then 9 months later--Negative.  I have had no exposures since 2009.  I have all sorts of weird things with my body that cannot be explained and doctor is lost.
1)Can I be ABSOLUTELY sure  I do not have HIV or syphilis with all my negative tests?
2) IS there a chance that ALL but the one positive tests for syphilis are false negative?
3)Do i need to test anymore?
4)Any chance that ANY strain/subtype of HIV can be missed with combo testing for hiv1/2 or do you need separate to be absolutely sure?
5)NO matter what is occurring with me, can i be sure that I am not a health threat to my wife?
Thank you

Welcome to our Forum.  I'll be please to comment.  You are a a "poster boy" for why we tell our clients that excessive testing is not a good idea.  Clearly your isolated positive FTA (a test which has a certain amount of subjectivity in its interpretation) was falsely positive.  the probabilities of false positive tests increase as the numbers of tests performed increase.  You need to accept you results and move on. 

1)Can I be ABSOLUTELY sure  I do not have HIV or syphilis with all my negative tests?

Yes, see above.

2) IS there a chance that ALL but the one positive tests for syphilis are false negative?

Simply not a reasonable interpretation of the results you report.

3)Do i need to test anymore?

No, please stop testing!

4)Any chance that ANY strain/subtype of HIV can be missed with combo testing for hiv1/2 or do you need separate to be absolutely sure?

Please stop testing and believe your test results.

5)NO matter what is occurring with me, can i be sure that I am not a health threat to my wife?

Clearly you are not a threat to your wife for any of the tests you have tested for. 

I hope these comments and answers are helpful to you.  EWH

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Thank you so much for answering.  From what I have been told these tests are final and absolute, but if you could clarify a few things and expand on them I would really appreciate it.
1)When you say that the FTA is subjective, how is that?  Isn't it a Yes or No result?
2)Is there EVER a time where after say even a year after exposure or even if you have LATE syphilis, that your treponemal(FTA. TP antibody, TPPA) as well as the RPR could be negative in serum blood tests but detected ONLY with spinal tap or is that not possible?
3)If i had been exposed earlier than thought, could a person be more infected an show all negative on HIV pcr, RNA and antibody tests?
4)Do the HIV tests cover essentially every strain out there?
5)NO MATTER WHAT symptoms I have, or how strange they are, I can FULLY put to rest these two diseases without a doubt?
Thank you

I will try to reassure you with questions which essentially repeat the reassurance I have already attempted to provide however your testing history and questions make me worry the you might benefit more from counseling to help you deal with continuing, unwarranted concerns than any amount of testing.  I say this out of concern for you, nothing more.---

Thank you so much for your reply. What really scares me is stuff my wife gets from time to time as well. Oral sores/unusual rashes. Out of nowhere. I know I've been tested but can you please answer these?

This is my third reply.  In it I will repeat much of what I have already said.  As my 3rd reply to your questions it will also be the final reply in this thread which will be closed later this evening. 

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