[Question #10162] Question #10116 Follow up - Hsv 1/2

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25 months ago
Hi Terri, I received results to the quest inhibition. 

Results as follows:
HSV-2 IGG screening index <0.90 (in range)
The HSV-2 IgG screening assay was repeated on a different platform as part of the inhibition test, and the result was negative; thus the Inhibition result could not be determined.
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25 months ago
My question is should I accept this and move on or do I need to continue testing? No symptoms have been noted as of 18 days post encounter. 

I’m nervous about another equivocal or false positive result. 
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Terri Warren, RN, Nurse Practitioner
25 months ago
You should wait about 8-10 weeks for a final IgG result after a concerning sexual encounter.  It is has been only 18 days since a concerning encounter, that is not enough time for an accurate test.  In the end, you may be negative, but 18 days is too soon to know with any certainty.  If you get a low positive or equivocal result, you can get another inhibition assay.  We've found good agreement between a negative inhibition assay and a negative western blot.  The same is NOT true for positive inhibition assays - we've seen those be negative on a western blot.

Terri
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25 months ago
Hi Terri,

In my initial question (#10116), you had noted that my exposure (protected oral and sex) carried a very low risk and “ If I were you, I would observe for any sores on your penis in the next week or so and if none appear, assume that you are not infected”. No sores or any other symptoms have been noted at now 22 days post exposure. 

While I understand that it takes time for antibodies to develop, I’m wondering if I should have tested to begin with based on cdc testing recommendations.  

1 - should I continue testing out to the 8 to 10 weeks recommended based on a one time protected encounter with no symptoms noticed?

Thank you again for your review and insight on this. 
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25 months ago
Additional questions below as response got cut off.

2 - what would the likelihood of the igg test again picking up rogue proteins and coming back equivocal or low positive again? The initial result I received 3 days post exposure really took a toll until I took the hsv2 confirmation test (quest inhibition) that came back negative (<.90 and in range).
3 - The confirmation test was just for hsv2 and there is no confirmation test for the HSV1 test that came back at 1.88. Being that the number was so low and my only exposure outside of my regular partner for the last 10+ years had happened 3 days before the test(theoretically I wouldn’t have developed antibodies from that encounter yet) that the 1.88 was a false positive? I tested negative for both hsv1&2 back in 2017. One would think if I had gotten hsv1 years ago that the number would be much higher than 1.88 and if I would have contracted it from the recent encounter that an igg test wouldn’t have picked up antibodies 3 days post exposure anyway as it was too soon after exposure for them to develop.
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Terri Warren, RN, Nurse Practitioner
25 months ago
That's the problem with the IgG test - false positives, which is why the CDC does not recommend that people do the test unless they have symptoms that make them thing it could be herpes.  
The 1.88 on the HSV 1 IgG could be real or also could be a false positive.  I've seen both true positives and false positives for HSV 1 at that level.  You are correct - the 1.88 would not be the result of a new infection three days prior.

My advice would be this:  If you can't put this worry behind you, do a herpes western blot instead of an IgG.  Then there is no worry about false positive or negatives.  

Terri
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25 months ago
Hi Terri,

I’d happily do the western blot but my understanding is I’d need to wait 12 weeks to do this. Being that my encounter was protected, does the 12 weeks still hold? If I could do the blot now, I’d love to do that and would welcome the opportunity to work with you if possible. Let me know regarding timeline and if now okay to proceed what I need to do to get on your calendar. 

I’m looking for options that could put my mind at ease as waiting out the 12 weeks would be challenging as I have not mentioned this to my long term partner.  

I had thought about another igg test somewhere in the 4-6 week range but am nervous about another potentially false positive result and then having to try and unravel that. 

I’m assuming my negative quest inhibition test puts me in the clear for anything other than the encounter (protected) from a little over 3 weeks ago as that is the only encounter I’d had outside of my long term partner of 10 years. 
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Terri Warren, RN, Nurse Practitioner
25 months ago
Condoms reduce transmission from women to men by 65% so though they are helpful, they aren't perfect and you should still wait 12 weeks.  You could do it now and repeat it at 12 weeks, as another option, albeit more expensive.  I can help you with this at westoverheights.com if you wish

Terri
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