[Question #10411] HIV RNA

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23 months ago
I am a male and had my possible exposure event with a female.
Two sessions in the same day.

First session, she was sufficiently wet for easy penetration and had sex for less than a minute.

Second session, not wet at all.  Had to force it in with spit and persistence.  Had sex for no longer than 5 minutes.  Both times unprotected.

Would a RNA test be warranted at 14 days based off my encounter?
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H. Hunter Handsfield, MD
23 months ago
Welcome back to the forum. Thank you for your continued confidence in our services.

You don't mention your location, but on quick glance at your previous threads, I believe you're in the US. In this and most industrialized countries, HIV is rare in sexually active women -- but of course this can vary. But even if your partner is a sex worker, the chance she has HIV is probably under one percent, maybe one chance in a thousand. And when a woman has untreated HIV, the average transmission risk for a single episode of unprotected vaginal sex is around one in 2,500. So before we consider any special risks, the chance you caught HIV probably is no higher than one chance in 250,000, and one in 2.5 million might be a better estimate.

Whether or not your partner was well lubricated makes no known difference in HIV transmission risk. The brevity of the first event suggests a lower than usual risk of HIV transmission.

For these reasons, from a medical or risk standpoint, you really don't need HIV testing at all. If somehow I were in your situation, I would not seek testing. That said, if you believe your partner is at particularly high risk (a lower cost sex worker, like brothel worker, street walker etc) or an injection drug user, the chance she has HIV could be higher and testing would make sense. And of course it is fine to be tested simply for reassurance; many worried persons are more reassured by negative testing than by professional opinion, no matter how expert. (We don't take it personally!) If so, you can either be tested yourself; or you can ask your partner to be tested. If she tests negative, you will know there was no risk and you can stop there. If this isn't possible or practical, then the best approach is to have an AgAb (4th generation, "combo") HIV blood test in about 4 weeks (98-99% conclusive) and perhaps another at 6 weeks (100%). An RNA test at 14 days will also be nearly conclusive (around 98-99%) if you feel you need earlier reassurance.

I hope these comments are helpful. Let me know if anything isn't clear.

HHH, MD
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23 months ago
I appreciate your in depth response.

When you lay out the odds the way you do, it really gives me peace of mind.

I’ve seen posts before with these statistics, but I thought I would give my specific situation.  Just in case I had an increased risk based on what I did.

Thanks for your help!
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H. Hunter Handsfield, MD
23 months ago
I'm glad to have helped. Thanks for the thanks.---
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23 months ago
Just to follow up.

I plan on doing the RNA at 14 days for reassurance.  Next Monday would put me at 14 days.  If it comes back negative.  Would the follow up AgAb test be needed at 4 weeks to confirm, or would that be overkill?
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H. Hunter Handsfield, MD
23 months ago
This is answered in my initial reply, the paragraph starting with "For these reasons...." All testing in your situation can be considered overkill. But if you feel you need 100% conclusive lab test evidence you aren't infected, disregarding all the other reasons, then the answer is yes:  you would need a follow-up AgAb test. Do I actually recommend you do that? No, I do not.

That completes the two follow-up exchanges included with each question and so ends this thread. Best wishes and stay safe.
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