[Question #10671] Still HIV symptoms, continuation #10565

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21 months ago
Dear Drs, my ongoing symptoms forced me to come back, i have swollen tonsills and mild sore throat almost since 3 weeks, short breath and general fatigue, still feeling achy and not well,   trouble to keep weight despite frocing myself to eat. My doctor did many tests all normal except the inflamation index CRP = 6 limit 5 and ESR=14 limit 10. My last tests were done in 2 different Labs on 17/11 at 8 weeks after exposure, both 4th generation ( Vidas biomerieux and Elecsys hiv duo) and Negative , i did an RNA test on the same day  but till date no result. 1) the negative 4th generation tests are conclusive? Cause  when I read the reference usually Dr Handsfield mention for the test conclusivity it is mentioned 99% and 100, could u please comment on this
2) Due to my current symptoms ( many symptoms resolved like insomnia and muscle and joint ache, I am assuming that I am fast progressor and not  producing enough antibodies to control the virus at this stage, if this is  the case, should the p24 be detected ? 
3) does ARS symptoms last that long (50 days), I know this can be related to poor prognosis and fast progression


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Edward W. Hook M.D.
21 months ago

Welcome back to the Forum although, similar to the response to your last set of questions, I’m sorry you felt the need.  I reviewed both our earlier interaction as well as your more recent interaction with Dr. Handsfield and confirm all that was said.  Specifically, the exposure you described DID NOT put you at any known risk for HIV and your subsequent testing has REPEATEDLY PROVEN that you did not acquire HIV from the exposure you have described.  Any continuing symptoms you have are due to something other than HIV.  If your continuing symptoms are not improving and continue to trouble you, I would advise you to seek the advice of your regular physician or an EAR, Nose and Throat Specialist.  Thus, in response to your questions:

 

  1.  Your tests are entirely, 100% conclusive.  In science no single observation is 100% but when a finding is repeatedly confirmed as your HIV test results have been, you can be entirely confident of the results.
  2. If your symptoms were due to HIV, either the p24 antigen, the antibody test or, when results return, your HIV PCR would be positive.  They are not.  Accept that you do not have HIV.
  3. NO!!!  The ARS does not occur out to day 50.  Virtually all ARS symptoms occur by day 30 following an exposure.

 

Your repeated posts suggest that you may be seeking information on the internet.  If so, please stop.  As Dr. Handsfield already indicated, the internet is full of misinformation, either because it is out of date, taken out of context, or just plain wrong. 

 

Finally, I must point out that we reserve the right to stop answering repetitive, anxiety driven questions.  Your repeat questions are falling into this area.  As a result, I will warn you that while you have two follow-ups remaining as part of this thread, once it is closed further repetitive questions may be closed without a response and without return of your posting fee.  This policy exists out of concern for our clients, nothing more.  EWH

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20 months ago
Dear Doctor Hook,
Thanks for your reply, 
- a clarification regarding my question No.3, what I asked if  the ARS symptoms last for 50 days? Because I am having symptoms since 3/10, some subsided some emerged later.
- Regarding your reply No.2,  sorry just i need to undestand, you said ''
If your symptoms were due to HIV, either the p24 antigen, the antibody test or, when results return, your HIV PCR would be positive'' , I thought after the window period is over (I.e. 42-45 days) the 4th gen combination test is enough to exclude the infection, am I right? Or in my case the PCR is warranted?
Thanks Doctor Hook  for your patience and  comprehension 
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Edward W. Hook M.D.
20 months ago
The ARS typical lasts 10-14 days.  It would not last 50 days.

Your PCR test was unwarranted.  Once a person has HIV, in untreated persons, HIV antibodies and/or p24 antigen are present and detectable going forward.  Tests for HIV are absolutely conclusive after 42-45 days.  Your results are (repeatedly) conclusive.  Further, since the symptoms of the ARS are due to the interaction of HIV antibodies and HIV p24 antigen, if your symptoms were due to  HIV, the 4th generation tests would have been positive.  EWH
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20 months ago
Dear Dr Hook, Thanks for your reply, I called the lab one week back and they told me that My test "HIV 1 RNA QUANTITATIVE" came back from the reference lab and the result is Undetected. I will not hide my concerns with regards to sample handling. Unfortunately, fatigue is continuing, swollen tonsills and lymph nodes under the jaw,  my joint and muscle pain came back, with weakness in limbs, not gaining weight. My questions: 
1- Given my symptoms do u suggest any more testing related to HIV 1 or 2. In which cases do u reccomend testing beyond window periods.
2- The combination of 4th gen test done in 2 different lab and RNA QUANTITATIVE at 8 weeks, supposed to be fool proof against HIv even in  the extremely rare cases when no antibodies are produced, am i right? Thanks in advance for your patience 
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Edward W. Hook M.D.
20 months ago
Thank you for the additional information.

1.  You have now tested for HIV 3 different ways, all tests are negative.  If you had HIV all would be positive.  Your results are conclusive.  I urge you to look for another cause of your symptoms.  I assure you that you do not have HIV.  Further testing for HIV, including for HIV-2, is unnecessary and a waste of resources.  
2.  Correct.  See my comment above.

We provide up to 3 responses to each client's questions.  This is my 3rd response and therefore the thread will be closed shortly.  It is time for you to leave you concerns about HIV and move forward.  Please don't worry.  EWH
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