[Question #10680] Chemo and HSV2

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20 months ago
Hello my husband acquired HSV2 from me about 10 years ago as I did not know I was positive from a previous relationship. However, he has never been tested but has had a handful of outbreaks over the years after the primary. Currently, he is going through radiation and chemo for head/neck HPV16+ cancer. He does NOT want to tell the doctors or be tested for HSV. I am SIGNIFICANTLY worried about disseminated and hepatitis with HSV. We are 3 weeks into treatment and so far he is fine. I have 400mg acyclovir at home, but unsure of what to do. He has forbid me to say anything to the doctors even about my own HSV status because he is embarrassed. I don't know what to do. Any advice? I have read those 2 things are rare and even resistant doesn't happen often. I am just lost and literally sick over this. 
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20 months ago
I was hoping if the doctor knew they could treat him preventative. I am aware that if his WBC bottoms out on the Cisplatin he could be headed in a very very bad direction. I would like to know what are the odds of it turning into something more significant than a bad outbreak? And how do I convince him to tell his doctor?
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Terri Warren, RN, Nurse Practitioner
20 months ago
Radiation in the head and neck area is unlikely to trigger and HSV 2 outbreak but it could.  I don't think you need to worry about disseminated or hepatitis HSV.  
Is he on suppressive therapy?  It would be 400 mg acyclovir twice a day if you would like to have him do that.  
Another way to deal with this would be for him to say he think's he's had a cold sore in the past and wants to start suppression so he doesn't get another.  
I don't feel there is any danger in just taking suppression but it might be good for his doctor to know if he's willing.

Terri
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20 months ago
Thanks Terri. He is also on Cisplatin chemotherapy as well. That is my biggest worry. I will try to have him talk to the doctors next week to get on suppressive therapy on his own. 
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Terri Warren, RN, Nurse Practitioner
20 months ago
The chemo could cause an outbreak as it suppresses his immune system.  Suppressive therapy will certainly help with that!

Terri
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