[Question #12170] HIV Likelihood After False Positive Testing Result

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9 months ago

I am currently on PrEP and get tested at my doctor’s office every three months. In September-December, I did refrain from taking PrEP due to lack of sexual activity but restarted my daily use and was on it for at least 7 days before restarting sexual activity. In early April, my standard HIV test came back as positive. I was told to immediately stop PrEP and to begin taking Dovato, and to come back for a “confirmation” test the next day. This confirmation test (both “HIV Ab/p24 Ag screen” and "RNA, Real Time PCR”) came back as negative. I then stopped Dovato, and did not take any medication for a period of approximately two weeks. I was then re-tested (“HIV Ab/p24 Ag screen” and "RNA, Real Time PCR” and a comprehensive blood panel), and all tests came back as negative for HIV. At this time, I restarted my daily use of PrEP. I have had repeated rapid tests and laboratory tests (both “HIV Ab/p24 Ag screen” and "RNA, Real Time PCR”) performed monthly since then and all have come back negative. My most recent was the first week of October, approximately 6-months after the positive test – this, too, returned as negative and no viral load detected. I was told by my doctor that I am, in fact, HIV-negative, and that it was most likely a false positive. How confident can I be in my results after this 6-month period?

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Edward W. Hook M.D.
9 months ago
Welcome to the Forum.  Thanks for your questions.  I'm sorry to hear of your falsely positive test result- such results are rare but certainly do occur from time-to-time, estimated to be less than 1% of the time for most people.  They can occur for a variety of reasons with the most common being technical issues somewhere along the multi-step process of sample collection, labeling, processing and reporting of test results.  Following your falsely positive result, your health care providers (and you) have done exactly the right thing and repeated tests using several different, unrelated tests (i.e. PCR, HIV antibody, and HIV antigen tests all test for different things).  The fact that you have had a number of negative tests since the single falsely positive result proves that the test result you received was incorrect and that you do not have HIV.  You will probably never know why you were unlucky but at this time you can be confident that the positive result you received in April was incorrect.

At this point I encourage you to be confident that you do not have HIV and to move forward.  EWH
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9 months ago

Thank you so much for your reply – I do have a follow up question: is it possible that the virus is “hiding” in my system? In other words, could the PrEP medication I take every day be keeping the virus suppressed despite the repeated “negative” test results?

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Edward W. Hook M.D.
9 months ago
I understand that your falsely positive result has shaken your confidence but if you had HIV the testing you have had in follow-up would have been positive.  I urge you to accept the overwhelming evidence that you do not have HIV.  EWH---