Dr. Hook..I do appoligize for repetitive questions. I ask out of concern, as well as some confusion. I'm the type of person that wants to be told the facts/truth. I don't like things to be sugar coated.
The reason I've been so persistent is because I'm worried my tests have been false negatives because of the Humira.
1. I've read that TNF alpha blockers(Humira) do effect the body's immune response to all infections.
2. Humira has a half life of 10 to 20 days, meaning it can stay in your system for 3 months.
I did alot of research on TNF alpha blockers and there effect on antibody production and HIV. There is something called Immune Reconstitution Inflammatory Syndrome which I'm concerned that is exactly what I've been going through.
I was on Humira before incident, as well as Prednisone. I believe that my immune system was immunosuppressed and I did in fact contract it. I started having symptoms within a couple of weeks, but at the time the Humira should of worn off the symptoms got alot worse. That's when the muscle atrophy started. That makes complete sense to me based off my symptoms, what I've read and the explanation of IRIS.
I came to this forum to seek the professional advice of yourself or Dr. Hansfield. If I had never taken Humira, I would have accepted my results a long time ago.
1. Have you ever seen or heard of a situation where medicines like Humira could cause false negative results for so long?
2. Could Humira mask HIV antibodies? I took a Gen 4 test at 16 months post exposure, but I took 2 doses of Humira a couple months before the test?
3. Could Humira interfere with the RNA/Antigen test?
Why is there so much confusion about RNA PCR testing? That's another reason I'm having a hard time with this.
1.RNA PCR testing is not a stand alone test.
2. RNA PCR test is a viral load test. I've read and was told that it is used for early detection and to monitor patients. I was told by an ID Doctor at MUSC that my 5 week and 12 month RNA tests didn't mean anything. He said that by 5 weeks that the HIV has left the blood stream and entered the actual cells themselves, making it undetectable with RNA PCR testing. I read at
12 months not everyone will have a detectable viral load, even people that are not taking treatment. That DNA PCR would detect at those times, not RNA PCR. So Iam very confused.
That's why I've turned to you and Dr. Hansfield. You are 2 world renowned experts. Honestly Dr. Hook, with all the symptoms and sicknesses that I've experienced since the incident I am physically a shell of my former self. I look and feel very sick. My eye sockets are sunken in, I ve lost 50% of my muscle and what's left has no tone. It's soft and squishy. I've been symptomatic for the last 4 weeks and I'm fighting Upper Respiratory and Bronchitis right now. The muscles spasms are going crazy too.
Hard to believe test results when I was healthy beforehand. It's like the floodgates opened after the incident.
If I wanted to do anymore testing, what would be the best test to have done other than an antibody test? I've read a DNA PCR.
Please repsond. My questions and concerns are legitimate? You're the expert. And I promise I won't post anything else unless I end up testing positive after all is said and done.