[Question #12741] ABOUT TESTS RESULTS
5 months ago
|
Hello doctors, I previously asked my question in the post code #15818. First of all, I know you warned me not to get tested, but to put my mind at ease, I had these tests on the 28th day. My VDRL-TPHA test for syphilis came back negative. I did not have a chlamydia or gonorrhea test because I did not feel any burning or discharge while urinating during this process. The real problem is with my HIV 1/2 test. HIV 1/2 antibody 0.06 (Negative<0.25>Positive) there is no problem with this test either. However, my p24 antigen test said ND (Not Determinable). I read that there are two reasons for this: either my body produced this protein excessively or I do not have enough of this protein in my body for the machine to detect it. Below the antigen result it was written: In some studies, antigen measurement values are so low that they cannot be read by VIDAS software.
(below the threshold value). In this case, the result is interpreted as negative.
Negative HIV-1/2 test results should be evaluated against suspected contact history and the elapsed time. Those with clinical symptoms and/or HIV
In patients with a history of high-risk behavior for infection, other HIV tests and follow-up should be performed according to the time since the suspected contact.
recommended. As I said, I did not experience any HIV acute phase symptoms during this period. But this result confused me a little.I have seen that people who had tested at the same place as me before had similar results. Of course, some of these people had it repeated on the 45th day and received a negative result, while some continued to be tested until the 90th day, but I did not see any positive results.
![]() |
Edward W. Hook M.D.
5 months ago
|
This is a good example of the consequences of unnecessary testing. Your p24 antigen test is almost certainly negative and the results are a problem with the test, not you. You have several options regarding how to evaluate this result further. These include
1. You can repeat the test, either now or at a later date. If you were infected the test would now be positive although with this strategy there is a risk of of another indeterminate result.
2. Alternatively you could get an HIV RNA PCR test. Results at this time would be entirely conclusive and I am confident, prove you are not infected.
EWH
---
5 months ago
|
Thanks for your answer.
1) If I were to perform the same test at a different lab on week 6, wouldn't it be too late? Because patients who got the same result at the place I was tested have experienced this frequently.
1.1) Or do you think the HIV RNA test would be more appropriate?
2) In other questions, you said that a 6-8 week result is more appropriate for syphilis. If I repeat the VDRL-TPHA test and get a negative result when I go to get tested for HIV, can I close the topic? Or is this test I took on week 4 the definitive result?
![]() |
Edward W. Hook M.D.
5 months ago
|
1. There is no such thing as “ too late”. When a test becomes positive, it stays positive.
2. 1.1. An HIV RNA PCR would be more definitive
3. Your 4 week test is virtually definitive. A test beyond 6 weeks would be definitive
One follow up remaining. EWH
---