I posted a question regarding my female NGU diagnosis about a week ago. If you recall, I was experiencing severe urethral pain with increased urgency and frequency to urinate.  It began about 4 days after protected sex with a new partner. Chlamydia/Gonorrhea/UTI/ bacterial vaginosis testing were all negative. My physician sent out Igg testing for HSV 1/2 which were both negative. Due to the excruciating pain and lack of other explanations,  he also did a scraping of the inflammation around my urethra and sent it for culture and started me on a course of Valtrex. I have been on Valtrex for about a week. However, I am still experiencing excruciating pain and I've started to notice tingling in my left thigh, yet still no lesions anywhere. My doctor finally took pity on me and prescribed Vicodin which does offer some pain relief, but it's only temporary. In the meantime, I was referred to a urologist. She didn't really offer any help, suggestions or hope. I asked about the possibility of using prednisone to reduce the inflammation and she told me to take Advil (eye roll).  She offered a cystoscopy, but also said she didn't really think we would gain much insight from it since the inflammation and pain appear to be on the outside because I have no markers in my urine to indicate cystitis or anything else similar. Moving on, the results from the culture came back yesterday, and the it was negative for HSV 1/2!! When I questioned the accuracy of the culture, the nurse told me I absolutely do not have HSV, in any form.  My doctor instructed me to go ahead with the invasive cystoscopy. I think he is at a loss for what else to do with me. Your input would be most appreciated. I want my normal body back! I've always been a very healthy person and this is wearing on me mentally and physically. The pain has been present for three weeks straight, and I don't know where to go for help.