Hi Doc, over last weekend (12-13 April) I had unprotected oral and protected vaginal sex with 3 different escorts a total of 4 times (twice with one of them). Now ten days later I have zero symptoms as far as I am aware. I did ask them if they get regularly tested and all of them said they do, ranging from 2 weeks ago to on January for when they last got tested. I’m due for an sti screening test tomorrow (10 days later) but I know it is too early to get any reliable results for syphilis & HIV. However I do understand that these two should be quite rare in my circumstances, and I’m quite confident that I’ll be negative for gonorrhea and chlamydia. My question is should I pursue testing again six weeks after exposure for Syphilis? From a purely statistical standpoint how significant is my risk for syphilis? Also would you say that given that there is no symptoms I would be alright to continue unprotected intercourse with my wife? Thank you.

Welcome to the forum and thanks for a well considered question. It is clear you understand the basics of STI/HIV testing.---

Hey Doc, thanks for the answer. I’m from Australia if that matters at all. I’ve heard that syphilis is on the rise in this part of the world, is it limited to only homosexual males? Thanks

Yes, syphilis is on the rise in Australia, but not across all populations. Mostly aboriginals, I believe. And gay men.---
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Hey Doc, thanks for the replies again. I think my following questions are bordering on anxiety at this point, but would it be possible for a chancre to appear in the urethral opening of my penis? What is a syphilis chancre supposed to look like? I noticed that the inside of my urethral opening is slightly red and almost looks swollen, however it does not look like a rash nor is it hard or painful to the touch. There’s no definite border either, it just looks like slight red swelling. Not sure if this is how it usually looks like and I’m just being overly anxious. Finally I do also have doxycycline at home, how effective is that in treating syphilis? Thank you.

Oh and to add there’s also zero pain whatsoever when I’m urinating. Just no pain in general.

The description of your meatus doesn't even come close to suggesting a syphilitic chancre. Just google the term, along with "photos" or "images". You'll find many examples and you'll see that you would not miss or misunderstand a typical chancre. And I agree this is anxiety speaking. My guess is that your meatus is entirely normal.---