I took 2 Truvada pills as part of the on demand 2-1-1 dose but I then had sex earlier than the prescribed 2 hours minimum. I had sex about 45 -60mins after the first dose. 

Can I be confident that my 2-1-1 dosage will still be equally effective if I take the remaining 24 and 48 hour doses correctly?

Such minor deviations in recommended timing are unlikely to have any effect on the effectiveness of PrEP on demand, but your own doctor/clinic might have a different understanding. They probably have just as much experience and knowledge about PEP and PrEP as we do, maybe more. In addition, PrEP on demand is not advised if potentially risky exposures are frequent. The available studies show PrEP on demand to be 85-95% effective, compared with 99% effectiveness for continuous PrEP. Based on your previous forum questions, I wonder if you're having new sex partners or other sorts of exposures that risk HIV that you should be on continuous instead of PrEP on demand. Also discuss this with your doctor or clinic.

Best wishes and good luck.

However, I met someone new and decided to take on demand prep. I tested the morning after exposure. We both tested negative on the home test kit. 

I just continued with the 24 and 48 hour doses of prep on demand though. It would be safe to say I never needed prep anyways right? Since we both tested negative.

I ask because some few online sources say negative antibody tests does not necessarily mean risk free if someone is in the window period. However, guidelines from local clinicians and doctors are that if these tests are negative, they don’t even prescribe PEP.