[Question #13054] Also Pep test conclusive too
2 months ago
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Questions:
Are my test results conclusive ?
If my PEP failed , would these test results still be reliable ?
Was the HIV-2 RNA PCR test qualitative or quantitative ? And is it conclusive ?
2 months ago
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Dear Team, I had oral sex (cunnilingus) with a sex worker. I held the vaginal fluids in my mouth for about 5 minutes and did not swallow. After spitting it out, I noticed a reddish substance that looked like blood(also i have bleeding gums to). I asked her, and she said she was not on her period
I took the first dose of PEP around 40 hours after exposure .I vomited approximately 25–30 minutes after the first dose , so I'm unsure if the medication was absorbed.
The second dose was taken around 73–74 hours post-exposure , and I continued the full 30-day course on time ,also 4th Gen HIV Ag/Ab Tests: Negative at 3, 4, 5, 6, 7, 8, 10, 12, and 17 weeks post-PEP (up to 120 days after finishing PEP)
HIV-1 RNA PCR (Quantitative): Negative at 14 weeks post-exposure (<80 copies/mL),HIV-1 RNA PCR (Qualitative): Negative at 17 weeks post-PEP,HIV-2 RNA PCR: <100 IU/mL; reported as negative (test type unclear)
1.Are my test results conclusive,this will not change in future to?
2.also assume If PEP had failed, would these test results still be reliable?
3.also that Was the HIV-2 RNA PCR qualitative or quantitative? And is it conclusive?
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H. Hunter Handsfield, MD
2 months ago
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Welcome back to the forum. Apparently you are asking about the same cunnilingus event as in your previous discussion with Dr. Hook 4 months ago.
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As Dr. Hook advised you then, you were not at risk for HIV. There has never been a proved case of HIV transmitted by cunnilingus, to either the oral or vaginal partner. That's true even if blood is present. Dr. Hook advised you that you did not need PEP and the you didn't even testing for HIV. Obviously you chose to disregard that advice. You also have been greatly over tested for HIV but the results prove you do not have HIV.
1. The results will not change in the future.
2. Your PEP did not fail; if that happened, your HIV tests would have been positive.
3. I have no way of knowing whether your HIV2 test was quantitative, qualitative, or both. Whichever it was, the negative result is reliable and conclusive.
I hope these comments are helpful. Let me know if anything isn't clear.
HHH, MD
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2 months ago
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Thanks doctor for your reply too
Also I want to confirm that
1.assume that pep failed my result still conclusive???
2.also what is the window period of pep(also consider the pep failure too)???
3.also I read your answer on healthtap were you have mentioned that pep prolong the testing result as 3 month post pep too is this same in case of pep late start or fail to
4.also as I started pep at 73-74 hour(assuming the first dose didn't absorb to) this doesn't delay the conclusion result too???
5.also as you said that cunnilingus (have blood) not result in infection(as I have blood in mouth 5 min) as I have bleeding gums to as per you it's still low risk(which doesn't need pep)
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H. Hunter Handsfield, MD
2 months ago
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1. Nonsense question. Whether PEP failed or not doesn't matter. You don't have HIV -- because you were not exposed and could not have been infected. Taking PEP made no difference except to delay the time to conclusive test results.
2. "Window period" makes no sense. Some diagnostic tests have window periods; treatments (including PEP) do not.
3. CDC recently released new PEP guidelines that suggest final testing after PEP be done 3 months after exposure, i.e. 2 months after the last dose of PEP. Your test timing exceeds these standards and therefore the results are conclusive.
4. Starting more than 72 hours after exposure makes your decision even more in error. Later than 72 hours often isn't effective anyway.
5. Try to think rationally. NO known cases of HIV acquired by cunnilingus. Over the decades, there must have been billions of cunnilingus exposures with one partner infected, and millions of those must have had blood exposure or bleeding gums at the same time. Still NO cases. What will it take to convince you???
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2 months ago
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Thanks doctor for your reply too
1.Also I checked the new cdc guidelines they included NAAT test too at 3 month post exposure for conclusive result I checked that guidelines 2 week before that lead me to test again as I already consider myself clear for this ,can you please tell me why they have added NAAT test at 12 week post exposure???
2.also as you said starting pep late make no difference as it can delay the test result although not more than 3 month post exposure hence at that time negative means you are negative too???
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H. Hunter Handsfield, MD
2 months ago
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1. No, I cannot tell you why the guidelines added the advice about NAAT at 12 weeks. I do know it was controversial -- that many experts argued against this. However, there is a tendency to "take no chances" and many health guidelines are more conservative than the science would suggest as necessary.
2. I'm not sure I understand this question. But I believe you can safely believe the negative results 3 months or more post exposure.
That completes the two follow-up comments and replies with each question and so ends this thread. Also please note the forum policy against repeated questions on the same topic. This being your second about this exposure and PEP it will have to be the last. Repeated anxiety driven questions are subject to being deleted without reply and without refund of the posting fee. We're not keen on collecting fees for questions with obvious answers; repeated replies often prolong anxiety rather than relieving it (there's so often a "yes but" or "could I be the exception" sort of thinking); and such questions have reduced education value for other users, one of the forum's goals. Thank you for your understanding.
I do hope the discussions have been useful. Best wishes to you.