[Question #13339] In need of advice

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4 days ago
Hi doctors- 3 years ago I (male) had unprotected receptive sex with another male or unknown status. I started PEP 22 hours later. However, halfway through my PEP I had unprotected sex with my boyfriend (he was the receiver). I completed my pep, and tested negative every 6 months since then. However, my guilt and anxiety is driving me crazy. 

1. Is it possible that I could have given my boyfriend hiv? Since I had sex with him before I finished pep.

2. Could hiv  in my system transferred to him, then cleared out of me after I finished PEP? 

3. I read many forums online that says “don’t have sex while you’re taking pep because you can pass it on to others”. Does that mean that I have infected cells while I’m taking pep, but then pep clear those infected cells up

4. Should I have told my boyfriend about the encounter so that he Could have gotten on pep himself? 
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H. Hunter Handsfield, MD
4 days ago
Welcome to the forum. Thanks for your questions.

You should be having no worries at all. Your negative HIV tests following PEP are 100% proof you do not have HIV and never did, even transiently. PEP does not merely temporarily suppress HIV then allow its regrowth. The drugs are effective in preventing infection within a few hours of the first dose. To my knowledge there has never been a reported case of HIV transmitted during PEP, if the PEP proved effective, as it was in your case. These comments pretty well address your specific questions, but to assure no misunderstanding:

1. Is it possible that I could have given my boyfriend hiv? No, it is not.

2. Could hiv  in my system transferred to him, then cleared out of me after I finished PEP? No. That is not known to happen.

3. I read many forums online that says “don’t have sex while you’re taking pep because you can pass it on to others”. That's a cautionary statement in case PEP doesn't work, e.g. if the HIV strain to which you were exposed were resistant to your PEP drugs. 

4. Should I have told my boyfriend about the encounter so that he Could have gotten on pep himself? No, there was no need. 

I hope these comments are helpful. All is well! Let me know if anything isn't clear.

HHH, MD
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4 days ago
Thank you for the quick reply doctor. So should I put this behind me? 

I know you said to my second question that it is not known to happen. However, is it scientifically possible for this to happen (giving someone hiv while on pep, then testing negative outside of the window period myself)? I know doctors can’t say anything with absolutely certainty. However, I just want to be reassured as this has been causing me a great deal of stress 


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H. Hunter Handsfield, MD
4 days ago
To the best of my knowledge, no:  this is not scientifically possible. But the fact that it's never been known to happen is the strongest evidence. Even though it is contrary to standard PEP advice, there must have been thousands of instances of people having sex with new partners while on PEP, maybe millions. And no known HIV transmissions. Please do your best to put this out of your mind and stop obsessing about it.
 
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4 days ago
Thank you doctor. Maybe this is just my OCD reading its ugly head. I do have last questions to close this thread:

1. My boyfriend has had a white tongue this last year ( I’m assuming thrush) it did get better one time when is sucked on ice. But it came back a short time later. Is this characteristic of thrush for HIV? 

2. From a pure medical necessity perspective, should I tell my boyfriend about the potential exposure so that he can get tested? 

3. Can you give me a simple explanation of how PEP works and why it would be scientifically impossible to give hiv to someone while I’m taking Pep, but never get it myself?
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H. Hunter Handsfield, MD
4 days ago
I'm glad to see you recognize your apparent OCD. It certainly seemed likely from your questions and your frankly irrational concerns about all this. If you continue to find yourself ruminating about it, consider professional counseling.

1. No. Coated tongue is a trivial everyday symptom of colds or almost any other minor health problem.
2. Repeat question. I advised against this above. But it's your relationship, not mine:  feel free to tell him whatever you wish. But there's no need from a medical/risk perspective.
3. Much too complex and potentially time consuming for this forum. Try an AI search (like ChatGPT) with a question something like "How does PEP work to prevent HIV infection?"

That completes the two follow-up comments and replies included with each question and so ends this thread. I hope the discussion has been helpful. Best wishes and stay safe.

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