[Question #13410] Follow up to [Question #13319]

 
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23 hours ago
Hi Doctors
Thanks in advance for your inputs. Since the last thread noted in the subject line, I have done a full STI panel including HIV 4th gen and RNA PCR at 12.6 weeks post exposure and 8.4 weeks post the last drug of PEP. All negative. My questions are:
1. I believe this now meet the CDC guidelines, can be 100% certain that I did not catch anything from the said exposure? 
2. I saw that the prior CDC guideline was to repeat test at 6 month post exposure. How confident are you in their change in assessment that seroconversion post PEP would have happened pre the 12 weeks post exposure mark? 
3. I continue to have a foliculitis, took 2 weeks of doxycyline, it helped a bit but some pimples are still there. Could this be another STI? Syphilis test was negative at 12 weeks (ab igg). Dermatologist did a biopsy and waiting results. 
4. ~2 weeks before the exposure I laid out in my prior question, I had insertive vaginal exposure to the same woman. It was protected, except for maybe <1 min which is why I did not take PEP after it. In case I had caught anything from her, would the fact that I took PEP 2 weeks later delay my seroconversion beyond my current timeline (ie 14.4 weeks post first exposure, 12.6 weeks post second exposure - which is the time I last had negative hiv gen 4 and pcr rna)?
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Edward W. Hook M.D.
23 hours ago
Straight to your follow-ups

1. I believe this now meet the CDC guidelines, can be 100% certain that I did not catch anything from the said exposure? 
Yes, these results absolutely prove that you did not acquire HIV from your encounter of concern

2. I saw that the prior CDC guideline was to repeat test at 6 month post exposure. How confident are you in their change in assessment that seroconversion post PEP would have happened pre the 12 weeks post exposure mark? 
I am confident, particularly with not only your 4th generation test but your HIV RNA PCR test as well

3. I continue to have a foliculitis, took 2 weeks of doxycyline, it helped a bit but some pimples are still there. Could this be another STI? Syphilis test was negative at 12 weeks (ab igg). Dermatologist did a biopsy and waiting results. 
Folliculitis is a chronic dermatologic problem for some persons.  Believe your tests.  The biopsy will show something other than an STI.

4. ~2 weeks before the exposure I laid out in my prior question, I had insertive vaginal exposure to the same woman. It was protected, except for maybe <1 min which is why I did not take PEP after it. In case I had caught anything from her, would the fact that I took PEP 2 weeks later delay my seroconversion beyond my current timeline (ie 14.4 weeks post first exposure, 12.6 weeks post second exposure - which is the time I last had negative hiv gen 4 and pcr rna)?
As I said above, your results are conclusive and should be believed.  I'm not sure why you are having such a hard time moving forward.

EWH
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23 hours ago
Thank you Doctor for your quick reply. Two follow up questions:
1. If PEP ‘resets the counter’ from an exposure count perspective (which is why some guidance is to test 4-6 weeks after last drug), why would the guidance not be to wait for 12 weeks post last drug of PEP instead of 12 weeks post exposure? 
2. I have read online about weird cases of co infection hep c and hiv and the fact that it delayed positive test results. I am not sure how credible this is. Would you agree that I am far along in the testing timeline that if I was co infected, one or both tests would have been positive? The hep c test I did was a serological ab test (as opposed to PCR)
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Edward W. Hook M.D.
20 hours ago
The data on follow up after completion of PEP are limited because failures are rare.  We are not aware of persons with negative tests 4-6 weeks after the last dose of PEP who went on to develop positive tests.

Please don’t look for information on the internet.  It’s full of misinformation and it’s hard to sort out what’s true and what’s not

One follow up remaining.  EWH 
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18 hours ago
Thanks Doctor. Could you keep the thread open? Would love to have the opportunity to use my 3rd question once the biopsy results come out (if needed). 
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Edward W. Hook M.D.
18 hours ago
I will leave the thread open until your next post, nomatter what the content. Please do not abuse this favor with further questions on other topics.  EWH---