[Question #13512] HPV Question

2 days ago

I believe I contracted HPV from a partner in 2010. Starting in 2013, I had regular Pap smears every year or two, all reported as normal, and no provider ever mentioned an HPV diagnosis. In 2021, after being diagnosed with stage 2 breast cancer, I underwent about 18 months of chemotherapy, surgery, and radiation. During this time, one routine Pap smear showed cervical cell changes, and I was informed for the first time that I had tested positive for HPV. I have had only one sexual partner since 2012. Because chemotherapy weakened my immune system, I wonder if the HPV infection could have remained dormant for years and then reactivated due to immune suppression, which might explain the previously negative HPV results.

Edward W. Hook M.D.

2 days ago

welcome to our Forum. Thanks for your questions. I hope your breast cancer management has gone well. You ask a good question. It is difficult to determine when you acquired your HPV infection.

You are correct however that processes that can reduce the strength of the immune response are associated with increase rates of abnormal PAP smears and HPV recurrence. These processes include aging and immunosuppressive medications, all of which can somewhat weaken the ability of the immune system to suppress chronic infections, including HPV, so it certainly is possible that your breast cancer treatment may have made recurrence of a previously suppressed HPV infection to occur. It is now important for you to get your regular follow-up of your HPV infection, working with your gynecologist. I do not know that this changes recommendations for management of your infection but would discuss it with your GYN.

I hope this information is helpful. EWH

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