[Question #13544] STD testing

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1 months ago
Dear Doctor, I previously asked about syphilis testing. You mentioned that a syphilis test can be considered conclusive at 6 weeks, but my current doctor says it’s only conclusive after 12 weeks. Could you please clarify the following:. What is the sensitivity of the test at 6 weeks — is it above 99,9%, or how should “conclusive” be understood? Are any specific test types more reliable or accurate than others after 6 weeks? Seems like there are different opinions on this? Thank you very much for your time and clarification.
 
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H. Hunter Handsfield, MD
1 months ago
Welcome back to the forum. Looking over your previous questions, it is clear you tend to over estimate the risk of STIs from various kinds of contact and as a result generally have been over tested following near zero risk events. And this question seems to concern the same exposure discussed with Dr. Hook two months ago. As he said at that time, "Testing for...syphilis...will be more than 95% reliable at 4 weeks and entirely conclusive at 6 weeks...." We stand by our advice regardless of alternate opinions on the topic. The reason for those is that despite a hundred years of experience with syphilis blood tests, there have never been precise studies of the timing to conclusive test results. That's why different experts can have different opinions.

Even though 12 weeks has often been cited, I have never seen or heard of a patient in whom it took more than 6 weeks for a conclusive test result. A complicating factor is that the answer may not be the same for different tests. In general, the newer syphilis screening tests -- those that detect specific antibody (the IgG and IgM T. pallidum specific tests, usually using EIA or similar technologies) may convert more rapidly than the older, traditional "nontreponemal" tests like VDRL and RPR. In any case, two other factors make syphilis almost impossible, assuming you indeed remain concerned about your exposures with a single female partner last August (described in your previous questions #13301. First, my understanding is that heterosexually acquired syphilis is exceedingly rare in Denmark; your partner was very unlikely to have it; and you had condom protected sex.

If you have had a negative test of any kind more than 6 weeks after the August events, you can safely conclude you do not have syphilis. However, if you would worry less and sleep better with another negative result, feel free to have another test, since you are beyond 90 days since the exposures.

I hope these comments are helpful. Let me know if anything isn't clear.

HHH, MD
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1 months ago

I had a new, similar exposure last week with a German contact in Barcelona, and I’ve come to the conclusion that I need to stop drinking and going out. I really hope this will be our last dialogue on the matter. I’d like to do a final test to get closure and then quit alcohol for good, as it clearly seems to be the root of my problem. My question fis: can I take a test at 6 weeks for reliable closure, or should I wait until 12 weeks? And what test is fasted?

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H. Hunter Handsfield, MD
1 months ago
Of course I have no comment or advice about your alcohol issues. As for the timing of a conclusive test, I can't say more than I did above. Here it is again:  "If you have had a negative test...more than 6 weeks after [exposure], you can safely conclude you do not have syphilis. However, if you would worry less and sleep better with another negative result...have another test...beyond 90 days" after the exposure you are concerned about."---
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1 months ago
Thanks doctor. I trust your expertise 100%. My last question would then be to ask, what test is most reliable and fast at 6 weeks? Again thx
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H. Hunter Handsfield, MD
1 months ago
The antigen-antibody (AgAb) tests -- also called "4th generation" are conclusive at 6 weeks. These are the standard lab-based tests used most of the time. For especially high risk exposures, the HIV PCR RNA ("viral load") tests are conclusive 11 days or more after the last exposure. You can use the forum search function to learn more about them; and many other online resources as well.

That completes the two follow-up comments and replies included with each question and so ends this thread. I hope the discussion has been helpful. Best wishes and stay safe. Please note the policy against repeated questions on the same topics. I do hope this discussion has been helpful to you.


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