[Question #13572] Reliability of test

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1 months ago
Greetings doctors,
I have been a frequent reader of your forums, since the medHelp days, and I refer to it when I have some questioning or want to learn more on the subject that people ask questions. 

I am a Heterosexual Male. In 2023, I did the following tests 9 months post potential exposure : Hiv Combo, Chlamydia(urine), Gonorrhea(urine), Hep c, Hep b and syphilis test, all of themnegative 
and after 12 months i did the following test : HIV Combo, Hep c, Hep b and syphilis test - all of them negative as well.
Reading your forum lately I had the following question : 

1)  Does having asymptomatic Ecoli or asymptomatic Hemophilus ducreyi, can affect the reliability of  the test "HIV COMBO " - the one that tests for the HiV 1 and 2 antibodies and P24 antigen for HIV 1? 
2) Does having asymptomatic Ecoli or asymptomatic Hemophilus ducreyi, can affect the reliability of these following tests : Chlamydia(urine), Gonorrhea(urine), Hep c, Hep b and syphilis test

Thank you in advance for your answer!


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Edward W. Hook M.D.
1 months ago
Welcome to the Forum.  Thanks for following our work.  I'll be glad to comment and hope that the reassurance that I'm about to provide will be helpful to you.

Your results are entirely reliable and should be believed.  The same result on two separate occasions rules out the possibility of a false negative test and your tests where taken at times when results are entirely conclusive.  BTW, hepatitis C is not realistically sexually transmitted and should not be a concern.

As far of your questions regarding the impact of asymptomatic bacteria, including E. coli and H. ducreyi, results affecting the results of your tests, that is not a concern.  E. coli is a normally found in the ano-genital area and H. ducreyi is extraordinarily rare as Dr. Handfield has mentioned to others in the past.  Further, as part of their development and approval processes, tests are routinely evaluated for any possible interference as part of their development processes.  E. coli and a variety of STIs are part of this testing process.  Thus:

1.  See above - your HIV tests are reliable
2.  Same answer- see above, your tests for gonorrhea, chlamydia hepatitis B and C, and syphilis are also reliable

Your test results are entirely reliable and should be believed.  There is no need for further testing related to the exposure you describe above.  It's time to move forward without concern.  EWH

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1 months ago
Thanks for your answer, dr,
I made a typo on the introduction : 
Actually Its in december 2022, I did the following tests 9 months post potential exposure : Hiv Combo, Chlamydia(urine), Gonorrhea(urine), Hep c, Hep b and syphilis test, all of themnegative 
and 12 months post potential exposure (april 2023) (not 12 months after the first test at 9 months) i did the following test : HIV Combo, Hep c, Hep b and syphilis test - all of them negative as well.

is it what you initially understood ? if not please confirm that your entire reply including both answer 1,2 are unchanged.

Thanks so much 
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Edward W. Hook M.D.
1 months ago
Thanks for the clarification on dates.  The change in dates does not change my assessment or advice.  Please don't worry.  EWH---
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1 months ago
Doctor Hook, I only see that you responded but can't see the content of your message. I've tried logging in and out but without success.
I will use my last follow up just to clarify for peace of mind so I won't lose sleep over this, it may sound silly and I apologize, but it's been stressing me a little.;
With my corrected intro and dates : 

In December 2022 I did the following tests 9 months post potential exposure : Hiv Combo, Chlamydia(urine), Gonorrhea(urine), Hep c, Hep b and syphilis test, all of them negative 
and 12 months post potential exposure (april 2023) : HIV Combo, Hep c, Hep b and syphilis test - all of them negative as well.

1)  Does having asymptomatic Ecoli or asymptomatic Hemophilus ducreyi, can affect the reliability of  the test "HIV COMBO " - the one that tests for the HiV 1 and 2 antibodies and P24 antigen for HIV 1? 
2) Does having asymptomatic Ecoli or asymptomatic Hemophilus ducreyi, can affect the reliability of these following tests : Chlamydia(urine), Gonorrhea(urine), Hep c, Hep b and syphilis test

A yes or no will do
Appreciate your time and thanking you in advance.



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Edward W. Hook M.D.
1 months ago
The corrected dates do not change my assessment or advice.

This completes this thread.  EWH
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1 months ago
I am not sure I fully understand as English is not my first language 

My last follow up question haven’t been answered. I know it’s similar to the ones in the initial post but for reassurance given the corrected dates I would appreciate if you can answer question  1 and 2 by saying yes or no and move on

I truely appreciate the time and effort 




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Edward W. Hook M.D.
1 months ago
Final answers.

1. NO
2. No

You need to stop worrying .  Closing this repetitive thread now.  EWH
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