[Question #13690] PEP Question

 
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2 days ago
Hello, 
I have completed 22 days of PEP and initiated it 30 hours after exposure; however, I recently forgot my pills at home and am traveling outside of the USA now.  
Will 22 days of PEP (Truvada + Dolutegravir) be effective? I know 28 says is recommended, but should I even worry about this. I appreciate your help. 
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Edward W. Hook M.D.
2 days ago
Welcome to the Forum.  Thanks for your questions.  I'll be glad to comment.  Unfortunately, the studies of PEP all used a 28 day medication duration and there are no good data on shorter medication courses.  I would guess that there would be a substantial reduction in risk of infection with 22 days but this is a guess not informed by clinical trial data.  

If you could tell me about the exposure that has led you to take PEP I may be able to further assess your risk for infection.  EWH
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