[Question #13709] Prc rna

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1 months ago
Dear Sirs, hello,
Firstly, I would like to thank you for your support and amazing work. You have helped me a lot in the past.
I would like to ask some questions: 

1) I am planning to take an Hiv Rna Pcr test around 15 days post exposure. Will it be conclusive? Will i need a confirmatory test at 45 test with a 4th generation test?

2) As I have been inconsistent with my thyroid medication for a long period of time and constantly mixing my doses (I was supposed to take 2 times per week t4 LEVOTHYROXINE SODIUM 150μg and 5 times per week 137μg LEVOTHYROXINE SODIUM but was mixing them for a long period of time, as I said, and thus taking some periods higher and lower doses) can this affect the result of the Pcr rna test?
 
3) The lab i will visit claims to do a "molecular detection (qualitative), but also quantification of the virus (measurement of the viral load in the blood of positive virus carriers)." Is this the Pcr Rna test? I am writing from South Europe.

Thank you, in advance.

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1 months ago
Ps. Also forgot to tell you that I have a stuffy nose and put xylometazoline HCI 0,05% to my nose. Could this affect the results?
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1 months ago
Ps. Also taking vitamin b12 supplements. 
Thank you again
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H. Hunter Handsfield, MD
1 months ago
Welcome back to the forum.

You seem to be far more nervous than seems to be warranted. An important principle:  there are NO medications, drugs, or medical conditions that alter the reliability or timing of the HIV tests. Your thyroid drugs and underlying thyroid problem, B12, decongestant spray, or stuffy nose make no difference whatsoever. And I mean NONE have any effect, including the most potent immunosuppressive drugs. (In fact, such drugs might make the HIV tests positive more strongly and sooner.)

1) The RNA PCR at 15 days will be conclusive. Many persons at risk and some of their doctors also advise an HIV AgAb (4th generation) blood test after 6 weeks, but it's really not necessary.

2) See above. Regardless of consistency of treatment, there is no effect whatever on your risk of HIV or your test results.

3) Yes, that wording is for the PCR test.

You don't say what your HIV risk is and why you are being tested for it. If you'd like to describe that situation, I might have more to say -- likely additional reassurance; it's up to you. In the meantime I hope these comments are helpful.

HHH, MD
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1 months ago
Thank you, Doctor.
On the 28th of December, after a difficult break up, I went out with friends to a small local bar/club. I had some drinks (mixed wine and vodka), and since I was on an empty stomach and am not a consistent drinker, my night became blurry, foggy from a certain point onward to the point of having some blackouts? Gaps? Parts I don't remember. 
I remember  flirting with a guy who is a friend of an acquaintance of mine (can't reach him)  and during the  big "blackout" I experienced, I only remember briefly kissing him. I don't remember how long this blackout lasted, maybe 20 minutes? 1 hour? 2?,  I have no idea. However, I am sure I never left the club. I also have a" flash" during this bkackout of being alone in the toilet and smiling at myself?
Anyway, after that, I regained my memory and was functional, though tipsy, however fully able to  chat, talk walk etc. Then I went home.
 The part that terrified me was next day, when my friend told me that she couldn't find me for quite a long time, though she admitted searching in the "wrong" place as she thought I was in corner "b" while i was supposedly in corner "a". When se finally found me that night, she told me that I reporterted only kissing this person and didn't seem to her being heavily intoxicated.
 However, as I tried to mentally reconstruct the night over the following days, I realized that the kissing part was extremely foggy with parts i dont remember and I started panicking. I began questioning whether I might also have had sex and simply don't remember it during the time i was supposedly missing and experiencing this "blackout".
I don't have any flashes or images of that happening and wasn't really worried till my friend "alarmed" me with the idea of the "missing part" of the night. 
That's why I decided to take the test, to rule out any unexpected sex I don't remember.
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H. Hunter Handsfield, MD
1 months ago
That's a lot more detail than I anticipated about your exposure, but honestly it doesn't sound worrisome. And HIV in such a situation is exceedingly rare. That said, reassurance alone is a valid reason for testing, even when the risk is nil. On that basis, it was reasonable to have the PCR test. But don't go overboard. That's all the testing you need.---
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1 months ago
Thank you, Dear Doctor and sorry for oversharing, I was overwhelmed and extremely stressed. 
I had a pcr rna test today at 18 days post the event and it was negative.
So no more testing right? Is it 100% conclusive?
I want to thank you again for all the amazing support. God bless you!
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1 months ago
Just a quick question, this event is in Greece. The test was done only for hiv 1, I shouldn't worry for hiv2 right?
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H. Hunter Handsfield, MD
1 months ago
Correct, the result is conclusive no more testing needed:  no surprise, but congratulations!

I don't know the frequency of HIV2 in Greece, but it's low in most of Western Europe, probably including Greece. The up-to-date HIV RNA PCR tests detect HIV2 as well as HIV1; here too I would assume such tests are normally done in Greece's medical labs -- but even if not, the chance you have HIV2 seems exceedingly small. Indeed, as you described your potential exposure, it seems likely you were not at risk for HIV at all.

That completes the two follow-up comments and replies included with each question and so ends this thread. I hope the discussion has been helpful. Best wishes and stay safe.


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