[Question #13721] Hiv rick

1 months ago

Here’s the translation to English:

“My father had contact with my blood during the period when I had ARS symptoms (when he was shaving/trimming the hair on my legs). My father’s hand at that time may have had cuts but was not bleeding, or he used the razor blade or toothbrush that had my blood on it, and afterwards he had symptoms and is currently experiencing prolonged inflammation.“

Edward W. Hook M.D.

1 months ago

Why are you asking two unrelated questions one after another.

You apparently do not know you had HIV ARS. Although Theoretically HIV can be transmitted through shared razors or toothbrushes the first thing to do is determine if your symptoms were the ARS. As I explained earlier, I doubt that they were. EWH

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1 months ago

So, my father touching my blood during the early stage of my infection would pose a risk if my father’s hand had cuts (not bleeding), or if he shared a toothbrush or razor afterwards?

The fact that an elite controller tests negative on 4th generation tests and rapid tests, only reacting to 3rd generation and Western blot, as in 1 out of 17 cases below:

https://www.tandfonline.com/doi/pdf/10.1310/hct1502-62

Would mean that such cases would be missed, wouldn’t it, sir?

I once read that there was a case where an elite controller transmitted the infection to his wife when the viral load suddenly blipped.

And there’s a report about viral load in blood being below the detection threshold, but the viral load in other compartments of the body and vaginal secretions (when inflamed) will be higher and capable of transmitting to others, if they don’t use immunosuppressive drugs like other patients do.“

Edward W. Hook M.D.

1 months ago

I cannot reach the link you provided however the fact is that elite controllers have positive antibody tests. N4th generation tests, like 3rd generation tests and Western blots have detectable antibodies. You do not know you have HIV and are misinterpreting suspect reports.

No change in my assessment or advice. You have one follow-up remaining. EWH

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1 months ago

Would a small amount of HIV virions reaching target cells such as CD4+ T cells in the thin inner foreskin mucosa—where CD4+ and Langerhans cells are abundant—be sufficient to initiate viral replication, particularly when this area has been ulcerated by friction? In the U=U studies using the 200 copies threshold, were participants circumcised or did they have intact, uninjured foreskin?

-What dose ofmethylprednisolone per body weight can cause immunosuppression during the symptomatic phase and potentially delay antibody formation? What is the latest time at which HIV antibodies may become detectable? Does it rarely happen or will it never happen?

-I have read that some elite controllers present strong HIV-specific CD8 responses but weak reactivity to gp120 and gp41 bands targeted by 4th-generation assays, leading to negative results, with only faint bands on Western blot or 3rd-generation tests—possibly because 4th-generation assays emphasize p24 sensitivity and may overlook weak antibody signals.

-In my father’s case, what level of risk would he face if I were recently infected while having a high initial viral load?

1 months ago

Sorry, my translation was inaccurate. What I meant about whether a rare event could occur refers to the first part of the question: if a hand contaminated with genital fluid after intercourse—containing virus—causes friction that leads to ulceration of the thin inner foreskin mucosa, where HIV target cells are present, then would just a few virions reaching those cells be enough to replicate and result in infection?

1 months ago

Would a small amount of HIV virions reaching target cells such as CD4+ T cells in the thin inner foreskin mucosa—where CD4+ and Langerhans cells are abundant—be sufficient to initiate viral replication, particularly when this area has been ulcerated by friction? Does it rarely happen or will it never happen? In the U=U studies using the 200 copies threshold, were participants circumcised or did they have intact, uninjured foreskin?

-In my father’s case, what level of risk would he face if I were recently infected while having a high initial viral load?

Edward W. Hook M.D.

1 months ago

This will be my final response. Following this there will be no further responses to your hypothetical questions regarding HIV acquisition risk. You have assembled scientific facts, information from scientific papers which appear to provide questionable conclusions and unwarranted fears based on events which carry little or no risk for HIV. A 4th generation HIV test or an HIV RNA PCR test will tell you if you have HIV. If you test, I anticipate that you will find that you don’t have HIV and then can work with your doctor to find out the cause of your problems.

HIV infections in most cases are cause by a single vision which infects T lymphocytes. To cause infection however persons must be exposed to thousands of viruses. Scientific concensus is that persons with viral concentrations of less than 10,000 virtually never sexually transit their infections to others and are considered non-infectious. Thus your questions regarding whether “ small amounts” of virus can cause infection show that you are using misinterpreted scientific facts to create unwarranted concerns.

While prednisone and other steroid medications are thought to increase vulnerability to all sorts of infection. Their role and the relevant dose are poorly understood and do not address your hypothetical question.

Hand to genital transmission of genital secretions is not known to virtually ever result in HIV transmission, irrespective of the presence of friction or even open sores.

End of thread. PLEASE DO NOT RETURN TO THE FORUM WITH FURTHER HYPOTHETICAL CONCERNS. I urge you to get tested. EWH

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