[Question #13938] Evaluation for HPV risk & throat discomfort

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1 months ago
Hi Doctors, I am a 23 year old male seeking an evaluation regarding potential HPV exposure and recent throat symptoms.
Exposure History:
 * Date: 70 days ago (Protected vaginal intercourse).
 * Context: Partner was a former sex worker; unknown STI status. (Netherlands)
 * Precautions: Condom used for the duration. No unprotected oral sex (given or received). No deep kissing. Had oral contact with breasts only.
 * Recent Activity: Around day 45 and 50, I’m concerned about potential autoinoculation (manual contact with penis followed by brief contact with mouth, touched on lips and tongue, got saliva.). This happened 3-4 times.
Testing History:
 * HIV: Negative (Day 21 RNA; Day 42, 47, 60 4th-Gen Ag/Ab). Just for context.
 * Vaccination: I have not previously received the HPV vaccine.
Current Symptoms:
 * No visible lesions, warts, or bumps on genitals (this makes it even more scarier, cause I read that the dangerous kinds are not showing up)
 * Persistent morning sore throat and occasional one-sided throat pain during the day.
I'm 23M, obese (will start a diet soon), I have high stress, I don't smoke, I don't get sick easily and I recover quickly in general. In the mornings I always feel like sick but I recover during the days. I believe this is because of heavy sneezing. My CRP (in regular blood tests) is generally 7-8 points above avarage. I wonder if this points to an infection or low immune.
Questions:
 * Is the risk of autoinoculation (genital to oral) significant in this context?
* Is there a way to get tested for HPV?
* Will I likely get cancer? If I do, when to look for symptoms?
* Is that cancer curable?
Thank you.
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H. Hunter Handsfield, MD
1 months ago
Welcome to the forum. Thank you for your confidence in our services. I'll try to help.

First and perhaps most important in reassuring you -- it's too soon for any symptoms due to newly acquired HPV. Genital warts and Pap smear abnormalities typically do not appear sooner than a few months after exposure, and up to a couple of years. While I cannot say that 70 days definitely is too soon, for sure it is rare. Second, there is nothing at all in your symptoms that fits with how HPV infections behave. They never cause any sort of pain or discomfort, other than warts, which once established weeks or months later can get irritated, itchy, etc (although even this is uncommon).

And certainly you describe no aspect of your exposure likely to have resulted in HPV infection. And since you could not have been infected genitally, you could not have auto-inoculated your throat. Finally there is no possibility of HPV causing the symptoms you describe and it cannot elevate the CRP test. You caught a cold.

1. There is no risk of HPV infection or autoinoculation.
2.There is no need or reason for HPV testing.
3. You will not get cancer from this.
4. Yes, most HPV cancers are easily and effectively treated.

HHH, MD
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1 months ago
Thank you for your answer Dr. This forum is really valuable for me.

I want to clarify one thing.
Even it was a protected sex, isn't there still a high risk from skin to skin contact?
If I got the virus from genital area skin, would I be able to pass it to my mouth even though there are no visible bumps?
 I was touching my penis and then mouth. Didn't fully touch the inside of my mouth but still, there was some kind of contact (like covering mouth with hand to get saliva, touching tongue a bit.) it happened a few times, multiple days.
Is it likely to pass the virus from genitals to mouth (not even sure I have the virus, but still.) like that?
And then from mouth it goes to throat and then years later, wouldn't it be able to turn into cancer?
Thank you doctor.
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H. Hunter Handsfield, MD
1 months ago
The notion of skin-to-skin transmission of HPV has never been about ANY skin transmission. It refers only to the mechanism of transmission during sex -- to distinguish those infections transmitted mostly by tissue contact (HPV, HSV, syphilis) and not sexual fluids (gonorrhea, chlamydia, HIV). But sex itself always is required.

But you didn't get the virus in your genital area. Even when present, genital to mouth autoinoculation is believed to be rare. And as discussed above, all this is going on much too soon since the exposure for there to be any risk.

The particular factors that raise the risk of cancer from HPV are not understood. The vast majority of HPV infections of all body sites, including throat, never cause cancer.
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H. Hunter Handsfield, MD
1 months ago
My previous previous reply in this space has been deleted for reasons addressed elsewhere. Despite your protestations, I still have to say your HPV concerns are way over inflated and there still are extraordinary parallels with the questions asked repeatedly by another user. But coincidences happen and for now you have the benefit of the doubt. Your more recent new question has been closed and your posting fee for that one will be credited. Please go ahead and ask your closing comment/question here.---
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1 months ago
Hi Doctor, thank you so much. This means a lot to me. You don't need to credit the amount, asking a question in this forum is already a blessing and it's only 25. I would pay hundreds or even more for your knowledge.

My question was:
Does HPV require direct skin to skin contact to infect?
Let's say, penis was covered with condom, in this case penis won't get infected?
Wouldn't it spread to penis later even if it does not start there first?
Also I had a small scar tissue (from a surgery) next to my penis, it is there for 1.5 year, itchy-dry area (when scratching, it turns into a white-ish dry skin, need to see a derm for that.). It was uncovered during sex and I had skin contact from there. Would HPV prefer this kind of an area? 
Thanks a lot doctor.
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H. Hunter Handsfield, MD
1 months ago
 Does HPV require direct skin to skin contact to infect? Yes -- or mucous membrane to membrane or skin.

Let's say, penis was covered with condom, in this case penis won't get infected? Correct, except of course sex usually involves some skin contact above the condom. In addition, during sex the penis may slide within the condom, working HPV (or herpes or syphilis) under the upper limit of the condom. These things are speculative, no data available. Still, these sorts of issues probably are the main reasons regular condom users get genital HPV almost as often as non condom users.

Wouldn't it spread to penis later even if it does not start there first? In males, the penis usually is the initial site of infection; or the anus and rectum in men who have receptive anal sex. In theory auto-inoculation to the penis from other sites might occur but probably is rare if it happens at all.

Scar tissue etc:  There is no reason to suppose such tissue might be more susceptible to HPV than anywhere else.

That concludes this thread. In conclusion, you need to understand that catching and having genital HPV infection is a normal, expected, and for the most part unavoidable aspect of human sexuality. Fortunately, most infections cause no disease and are not noticed. The main prevention strategy is vaccination to prevent infection with 9 of the 100+ HPV types that cause ~90% of sexually acquired infections and 90% of disease episodes like warts and cancer. Then simply don't worry about a minor problem that should not be bothersome.

I hope this discussion has been helpful. Best wishes and stay safe.
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