[Question #14007] Why discrepancies in testing window guidance?

 
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10 hours ago
Perhaps a bit academic, but I’m wondering why there are such meaningful discrepancies in guidance on how long to wait for an STI test. Less so for syphilis, HSV, and HIV. But much more so for gonorrhea, chlamydia, and trichomoniasis. 

In your forum, you often say NAAT urine testing results are reliable 4-5 days post the last exposure. But a lot of online guidance says tests are not reliable until 7 or even 14 days post exposure. Why is there such a discrepancy? And what research or data gives you confidence on the shorter time windows? This isn’t to challenge your expertise (as I believe you), I’m just trying to understand where the guidance comes from. 

I can see an argument (mentioned elsewhere) for orgs to try and be conservative to ensure a test’s sensitivity goes up to ensure fewer false negatives. But I can just as easily see an argument for people knowing their status quickly so that they don’t risk infecting others. 

I’m also curious if the actually sensitivities of tests are known clearly after certain waiting periods. I saw something about some tests only being 50%-75% sensitive by day 7, which would seem too low to have confidence in results. But I have no idea if that’s a guesstimate or backed with real data. 

Anyway, can you help unpack what’s going on here?