[Question #2319] HSV2 - False positive/negative on IgG Tests

45 months ago
About 2 years ago my partner at the time had his annual STD tests done and they came back positive for exposure to HSV2.  Due to a miscommunication between me and my ob-gyn, apparently I had only had swab tests done with my annual exam for the previous 3 years, but no blood tests.  I had updated blood tests done, and the Herpes 2 Ab. (IgG) came back positive at a level of 3.3 HI.  I contacted my two previous partners, and both had their tests come back negative.  I assumed I had contracted HSV 2 from a one night stand prior to those two partners, although it had been protected sex.  I moved on under the assumption that I had an asymptomatic version of HSV2, since I've never shown any signs of symptoms.  I have never taken any kind of medication for HSV.

I had a full panel of STD blood tests done this May before starting sexual relations with a new partner, and the HSV 2 IgG came back negative at a level of <0.91.  Based on my reading, it seems that the IgG is usually the most accurate of tests.  How common are false negatives and/or false positives?  Is there a better way to be testing for this?  I want to be sure to accurately describe any medical concerns to my current and/or future partner(s).  Thank you!
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
45 months ago
The IgG is NOT the most accurate of test - the most accurate is the herpes western blot done only at the University of Washington in the US.  Given your highly discrepant results on this test, I would advise that you consider getting the test.  It cannot be done through another lab, like Quest or LabCorp.  It must be done directly through the University of Washington.  You can call 206-685-6066 to order the kit yourself, but you will need a clinician to order the test.  You can ask your own provider to order this for you on the lab requisition - if they cannot or will not, I can order this for you through our clinic website, westoverheights.com, the video conference button.   Please let me know what other questions you might have.

Terri
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