22 years ago, I started having vulvar burning, vulvar vestibulitis. The skin was red & burned. I couldn't wear clothes with lycra/spandex/synthetics. Sitting & sex burned. 2-3 years later, lesions appeared. My doctor thought they were warts, & froze them off, & then gave me interferon injections. He said he couldn’t do DNA typing for vulvar warts. I got better & felt normal for 7 years. Then I started having occasional mild, abn. probs. In 2012, I again couldn't wear spandex. In 2013 five bumps were seen & burned off. Again, no HPV DNA typing, because it was on my vulva. I still had some difficulty with clothes, but no lesions visible, so I gave up. By 2015, my pain level was where it had been years before; clothes, sitting, etc, hurt. I gave up & lived with it until June 2017, when I went to the doctor & she saw lesions that she described as vesicles. She said it looked more like herpes, & tested, but the test was negative. She assumes it’s warts. She said Imiquimod would be best. But I read that it’s bad for vulvar vestibulitis. She suggested cutting it out; but I read that cutting could cause permanent pain. She said she could biopsy for cancer, but not type the HPV, and then freeze it off, but said that wouldn't kill the virus in adjacent tissue, so I'd probably get more warts and the pain might continue. I also now have rectal prolapse, which causes chronic mucus that irritates the tissue. I try to get rid of the mucus, but it comes back soon after. I need colon surgery, but have not figured out the best option. Can you tell me the best treatment, for me, for the warts & surrounding infected tissue? How can I get the virus into remission? Someone said Gropinosin and beta d glucan helped a friend with HPV. Gropinosin isn’t available in the US, but any thoughts about it?