[Question #2734] Herpes blood test still negative

42 months ago
Hey Terri,

So I tested positive from a swab test experiencing my first outbreak n only outbreak back in late April 2017, fast forward to late sept 2017 about 5month, I went to anylab because I want to know what type of HSV I have and both read <0.91 which means negative. I’m just trying to find out which one I have. Also never had a cold sore on my lip in my life either. I been on valtrex everyday since too. Is my blood count for HSV low or something? How long do I have to wait? Those tests aren’t the cheapest. Also any updates on vaccines? According to justherpes.com  they said with medication and no outbreaks occurring but no condom use the rate of transmission is 2% does that sound accurate? Any new studies? I’m anxiously waiting for the first vaccine to come out. Theravax just got 7mill and even though their not fda approved their more promising then the Gen I believe. 
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
42 months ago
If you have taken Valtrex every day since you were diagnosed, you have likely prevented antibody development which in itself, isn't a bad thing as you are basically taking the place of the antibody response with the medicine, except that now you can't find out the type.  either that, or you have HSV 1 and the test misses 30% of HSV 1 infections.  I would recommend that you come off the medicine and 1) have an outbreak that can be swabbed AND that swab typed as it should have been in the first place or 2) wait about 2-3 months and get another IgG test. 

As you may be aware, the whole Theravax thing is under intense scrutiny because it was done out of the US and outside of the normal scrutiny required to assess success or failure.  And the major investor that you describe has now made the statement that he wants the future trials of this vaccine to be done to FDA standards.  Once that happens, we can get a clear picture of the efficacy of the vaccine.  Genocea on the other hand has been very careful studied and has been successful so far - it will move into phase 3 trials soon if it hasn't already.

I don't know your gender so I can't help you with the transmission risk part.

Terri
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42 months ago
Ima man. 30yrs old. We’ve spoke plenty times before but I know it’s hard to keep up with all of us. I really don’t want to get off the medicine cus I don’t want to experience another outbreak and I’m pretty sexually active. I. Guess I’ll wait it out a few more months. And let’s say it was HsV1 does that mean if I receive oral sex then she can get hsv1 easier on her facial lips and then if I kiss her for whatever reason I can get hsv 1 on my lips too. Cus I only have genital herpes and that I know is a fact I jjust don’t know which one. And yeah theravax will goe through FdA but most likely they’ll pass all phases but that means it could take 5yrs which is the bummer. At the rate of the Gen, when do you think that one will be available? like another year? Have you heard of Aicuris Pritelivir in Germany, that sounds very promising too. 
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
42 months ago
sorry,  you're right, it is difficult for me to keep track of everyone as many people use the same name when posting.  As long as you are on daily medicine, testing will not be useful.  If you have HSV 1 and someone gives you oral sex they could acquire this orally, though that is unlikely because HSV 1 isn't shed from the genitals often.  It is unlikely that you would get this orally by kissing someone with HSV 1 if you have it genitally but since you are not currently mounting an immune response, due to the daily medicine, it's more possible.  It's a trade off, huh?
Our clinic did the trials of both AiCuris and Genocea.  The AiCuris trials were stopped due to side effects seen in the animal model.  Genocea is proceeding but it will most certainly take longer than a year.  And honestly, it is likely to used for people with HSV 2 at first, not HSV 1 but probably in the future, will be available to both.  I have absolutely no idea about Theravax.  Given it's very rough start, that one may take a lot longer.  I just don't know.

Terri
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42 months ago
So what do you think is better to have genitally, out of these two, HSV1 or 2, goin off transmission and also vaccines in the process. Also if Gen is about to be on their last phase, if that all goes good, it shouldn’t be more than two yrs for availability wouldn’t you think?  Also if I was to get off the medicine would I start producing more herpe cells?  Doesn’t the medicine slow the production of herpe cells or what does it control exactly, would things change if I stopped the medicine for a few months and then got back on it after I have a outbreak. What if I take 3 pills a week instead of everyday. And also since u know I’m a man, what is my transmission rate again with no condom, but medicine valtrex daily and no outbreaks. Cus I wanna have some babies one day soon
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
42 months ago
well, certainly HSV 1 is better, but who has a choice? 
I don't know if the phase three trial is even underway, but I think two years is optimistic. 
If you stop taking medication, you will start producing antibody of your own, correct.  And if you stop for 12 weeks, you can get a more accurate antibody test.
If you have HSV 2 and take daily medicine and use a condom, the risk of transmission is around 1-2%, having sex about twice a week.

Terri
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