[Question #3002] Hiv worried lot

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93 months ago
Hello dr,
On 5th september i went to csw in canada. She was a cheap one and was asian. Later i came to know that she give her service without condom by charging double. So now during sex she used thin condom. I had protected oral and vaginal sex. However during sex on the tip of penis condom was baggy and wrinkeld from 1 side and the otherside looked like that there is no covering. It was bit dark overthere so i was not sure. After ejaculation she quickly removed condom. I was not worried about this incident.on 6th october i had sore throat which was more irritating in morning next day. I am not sure about fever because i started taking tylenol due to sore throat however i would be very very mild if there was because i was working my daily routine.sore throat continue for 4-5  days and i was having trouble speaking.  On 12th october i went to doctor  my tempeprature was normal she prescribed me medicine  for throat and cough. On 17th october i went to sexual clinic nurse asked me for the time of exposure . To be honest i lied i told 12 weeks but it was 6 weeks she did a rapid blood test it came negative. I was still worried i went to another clinic in toronto on 26th october after 51 days of exposure.they conductef combo ab/ag test it also came negative. Felt relaxed .but those symptoms give me sleepless nights..
1. Are my results conclusive?
2.should i worry about symptoms?
3.for worse scenario if condom had broken and symptoms should i relax after testing?
4.if my symptoms were due to hiv would i have tested positive  on tests donror should i take another test. As i have heard about second window period.
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H. Hunter Handsfield, MD
93 months ago
Welcome to the forum. Thanks for your question.

Bottom line:  One hundred percent certainly you do not have HIV. The AgAb (combo) test for HIV is among the most accurate diagnostic tests ever developed, for any medical condition. If done sufficiently long after the last possible exposure, the result is always conclusive -- and that time is 6 weeks. Your negative result 51 days after exposure proves you were not infected. The results always overrule exposure history and symptoms. Even if you had had a particularly high risk exposure (you did not, because of the condom) and even if your symptoms were typical of a new HIV infection (they are not), the test result is conclusive.

Those comments address all your questions, but to be sure there is no misunderstanding:

1,2,4) Yes, conclusive, assuming you haven't had another more exposure. The symptoms cannot be due to HIV if you have not been reexposed in the past 4-5 weeks. No further testing is needed. If your symptoms persist, continue to work with your doctor, but they aren't from HIV.

3) Yes, the test result overrules a condom break. (Even without a condom, your risk would have been low. If a woman has HIV, condomless vaginal sex has an average transmission risk of once for every 2,500 exposures.)

I hope this information is helpful. Let me know if anything isn't clear.

HHH, MD

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92 months ago
Thanxx doctor. I just have some queries more. I m quite sure about results but i have 1 doubt  hope you will clarify this that my symptoms were from 6th oct to 12 october. 1.I was fine after that so if those symptoms were related to hiv would i have been tested positive on tests done after that one rapid antibody on 17th oct and another on 26th oct combo?2. When are antibodies  actually on detectable level on begining of symptoms or when symptoms are gone ? 3. 4th generation test was done after almost 3 weeks after onset of symptoms any chance  of misdiagnois or undetectable antibodies at that time?
4.CDC says 90 days conclusive and in canada tests  are too conservative like my nurse was not even willing to do antibody test before 12 weeks any comment on that?
 Thanxx dr i know i am bit anxious but i dont want to be misdiagnosed because this can later bring fatal results. Sorry for disturbing u hopefully you will clarify my doubts and i will move on
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H. Hunter Handsfield, MD
92 months ago
1) Correct.
2) Antibodies usually appear about the time symptoms start, and are then detectable for life. More important, you blood was tested for both HIV antigen and antibody. It is not possible to have HIV and have both of these undetectable at 51 days, i.e. to have a negative AgAb test.
3) Doesn't matter. Your test was negative at 51 days. The earlier results are irrelevant. (But they also were highly reliable in showing you didn't have HIV.)
4) CDC still has a conservative stance that recommends testing at 3 months. It is scientifically unnecessary and most expert organizations advise 6 weeks if an AgAb test is ued.

Don't overthink all this. Your test results PROVE you do not have HIV. You can move on without worry and without further testing.
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92 months ago
Thanxx doctor so u have given a lot of valuable information to me. I appreciate your knowledge and u r doing great job by helping people like me. Please dont mind i have 1 more query that in one of your post u said that antigen part in these tests are not sensitive i dont remember properly it was something like @determine.  I wont go for further testing. Actually i was earlier afraid to go for further testing due to negative thoughts that this time i will get bad news but u have given me kind of relaxation. Thanxx doctor god bless u 
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H. Hunter Handsfield, MD
92 months ago
Yes, for a while the Alere Determine test had a problem with the antigen component of the test, so it was functioning more like a 3rd generation antibody-only test. But the company rapidly corrected the problem. Determine is believed to now function as designed.

But I will add that this final quesiton shows you're still looking into the details of all this far more compulsively than is necessary and perhaps healthy. Probably nobody in the world has ever had the test results you did, at those intervals after exposure, and still had HIV. It doesn't happen, and the biological details why really shouldn't matter. Do your best to move on and stop searching the internet about all this!

I hope the discussion has been helpful. Best wishes and stay safe. 
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