[Question #3754] Could antibodies in an HSV blood test be caused by something other than HSV?

34 months ago
Hello,

I recently tested positive twice for HSV-1 using the EIA blood test, at two different labs (index values of 8.3 and then 4.83).  I have never had an outbreak.  I do however suffer from severe allergies and eczema.  After doing some research, I discovered the people with certain immune system issues including allergies and eczema have higher than normal levels of certain IgG antibodies (although I could not ascertain which ones, although subclass 1 was mentioned).  So my question is, if these immune system conditions could cause the body to create increased levels of IgG, would it be possible for those levels to create a false positive during an HSV blood test that is also looking for certain IgG antibodies?

Thanks in advance.
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
34 months ago
No.  The antibody test for herpes is specific to that virus.  It looks only for proteins associated with antibody to herpes.  In our study everyone with an index value on the Igg of >3 confirmed by western blot.  As you probably know, about half the US population has HSV 1 infection, most often in the form of cold sores, so you are certainly not alone.

Terri
---