[Question #4108] Accuracy of blood test for HPV

30 months ago
I already said I have a fleeting oral exposure. I did take oral HPV DNA test and it came back negative. I went ahead and took the vaccination  3 months ago. So far I took only two shots. I found a lab who does a blood test for HPV.  I have given the blood. They said they will find past infection. I am concerned about false positive. The lab claimed even if HPV is cleared by your body they can find it.  I did not tell the lab that I started the vaccination. How much vaccination will interfere with the blood test? will it be correct?
Edward W. Hook M.D.
Edward W. Hook M.D.
30 months ago
Welcome to the Forum and thank you for your question.  Blood tests for HPV are research tests and are not recommended for patient care.  Further, such blood tests will detect antibodies for HPV and, since you have had the vaccine, I would expect your blood test to be positive.

EWH
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30 months ago
I remember one of Dr. Hunter's answer where he said HPV DNA Vaccine has nothing to do with blood tests.  Also, is there any blood test that could detect past infection that is cleared by our body?
30 months ago
Also, if I had infected for a strain of HPV, I assume vaccination will not work for that strain. I already have an immunity to that strain.   I guess I will  not have high positive for that strain.
Edward W. Hook M.D.
Edward W. Hook M.D.
30 months ago
The HPV vaccine you received is virtually certainly an protein vaccine that leads to antibody formation.  As I said above, there are no commercially available, FDA approved HPV blood tests, only research test as I mentioned above without good data on the performance characteristics. 

With regard to the vaccine, the vaccine causes far higher antibody levels, in general than naturally occurring infection.  Trying to differentiate your infection status based on the strength of your antibody levels is of unknown value.

I have no idea why you want to test.  Testing will give you only UNRELIABLE results.  EWH 
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30 months ago
Ok. I will not follow up on the test. I am wondering what’s your view on therapeutic vaccine for HPV.  I see people are reporting success and say eliminate infection with no remission. Some of them has gone through clinical trial 3.  I am not worried about HPV.
My exposure is unlikely for HPV transmission. I  am asking in general
Edward W. Hook M.D.
Edward W. Hook M.D.
30 months ago
I agree, the exposure you describe is quite low risk for acquisition of HPV.  I support your decision to not pursue the test.

The companies which make the vaccine state that there is no proven therapeutic value to receipt of the vaccine, i.e.  there are no data to suggest that existing HPV infections are effected in any way by the vaccine.  There are some ongoing research projects which are continuing to evaluate the possibility that the vaccine might help with resolution of existing HPV infections but the results so far are not so hopeful.  The studies are ongoing however. 

I hope my comments have been helpful to you.  This is my 3rd and therefore final response to your questions.  Take care.  EWH
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29 months ago
Update: I just got back from my partner who did HPV DNA test. She said it is negative. Should I still be worried about HPV? 
Edward W. Hook M.D.
Edward W. Hook M.D.
29 months ago
I would not be particularly worried.

The thread is closed.  EWH
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