[Question #4348] cervical cancer or hiv

28 months ago
I am 36 year old female.  I have hpv.  I have had warts in the past and currently do as well.  I tested negative for HIV 3 weeks after the last possible encounter.  I recently went to doctor because of swelling in my hands and heart palpitations.  They did blood work.  The test that came back was elevated ANA speckled titer.  I have not had a pap smear in over 2 years.  Could the elevated ANA test indicate HIV or cervical cancer?  This is causing me severe anxiety. 
H. Hunter Handsfield, MD
H. Hunter Handsfield, MD
28 months ago
Welcome back to the forum. I'm glad you haven't felt the need to return until now, since you asked three questions in rapid succession about two years ago. I hope that means my and Dr. Hook's advice back then was helpful to you. Still, I'm a bit disappointed you remain as concerned as you are about HPV and HIV.

Speckled pattern on antinuclear antibody (ANA) testing is statistically associated with various autoimmune diseases, including systemic lupus erythematosus (SLE), Sjogren's syndrome, dermatomyositis, and others. However, many or most people with this result are entirely healthy and remain so. There have been a few case reports of people with both HIV and positive ANA (speckled and not), but such cases are rare and there is no known association of speckled ANA (or any positive ANA result) with HIV or with HPV disease. The reported cases probably were just people who randomly had both problems, neither causing the other.

I'm a bit skeptical you still have genital warts that have lasted more than two years, and have to wonder whether that diagnosis (or your perception of having warts) is accurate. As for HIV, you haven't described your current risks, so I really can't judge the possibility you might be infected. A negative antigen-antibody (4th generation) HIV test 3 weeks after exposure is around 90-95% reliable, and if your sexual lifestyle has remained as described a couple of years ago, you're at very low risk for HIV and I very much doubt you are infected.

I hope these comments are helpful. Let me know if anything isn't clear.

HHH, MD
---
28 months ago
I just had the hiv oraquick test on Wednesday and it was negative so that is ruled out. So now just awaiting appointment with a Rheumatologist for the abnormal ANA levels. That’s for all of your advise and help. 
H. Hunter Handsfield, MD
H. Hunter Handsfield, MD
28 months ago
Thanks for the follow-up. Glad to hear your HIV test was negative (but of course not surprised). Thanks for the thanks about our services; I'm glad to have helped.---