You said, "any such effect of antidepressants on HIV probably is trivial and unimportant." but the article suggested "The SSRI significantly downregulated the RT response in both the acute and chronic infection models. Specifically, citalopram significantly decreased the acute HIV infectivity of macrophages. Citalopram also significantly decreased HIV viral replication in the latently infected T-cell line and in the latently infected macrophage cell line. There was no difference in down-regulation by depression status." 

Big thanks! 

Thanks so much

Dr. Handsfield and I have discussed your repeated, repetitive questions.  It appears that either you have not read our earlier responses or have not understood them.  One other possibility is that you are placing entirely too much thought on a single obscure article found in an obscure journal. Please understand that all journals are not created equal and there are an increasing number of journals which now publish articles which are factually incorrect, scientifically flawed or propose unrealistic conclusions.  The article you are so focused on says nothing that should influence your behavior when it comes to HIV and HIV prevention.  The data are not statistically significant, have not been confirmed by other scientific studies despite the passage of 8 years since publication, and, as Dr. Handsfield indicated, caution readers that their data are insufficient to guide decision making by persons at risk for HIV.  

Please understand that the medications used for therapy of HIV, for PrEP and for PEP act DIRECTLY on the virus to stop its growth, in contrast the UNPROVEN action of antidepressants suggested in this paper is INDIRECT and does not act on the virus but the host immune system (macrophages).  Thus even if the effect suggested by the article were confirmed, it would NOT be expected to stop infection, just slow it.

Please GIVE UP on the findings in this article.  You are misinterpreting the significance of what you are reading and being misled.  Persistent, repetitive questions will lead to banning you form our site. EWH

You said, "Thus even if the effect suggested by the article were confirmed, it would NOT be expected to stop infection, just slow it."

2. what is the meaning of this, ""The SSRI significantly downregulated the RT response in both the acute and chronic infection models. Specifically, citalopram significantly decreased the acute HIV infectivity of macrophages. Citalopram also significantly decreased HIV viral replication in the latently infected T-cell line and in the latently infected macrophage cell line." does it mean it decreased the virus and therefore the antigen production. And if the effect is not significant, then why did they mention "significantly decreased" 

You are still focused on irrelevant details:

1.  Unknown, and predictable, if any slowing occurred at all.  In my judgement there is unlikely to be any slowing.

2.  REPETITVE.  STOP!!!!!!!  This means they think that viral growth MAY have been slowed, not stopped.  This would not prevent infection..

I feel that responding to your questions is a waste of my time and yours.  You need to give up and forget this article.  EWH

thanks for all the answers sir

when they mentioned "significantly" i became really concerned. what are the  'RT response' and 'latently infected T-cell line and in the latently infected macrophage cell line'? I just want to know this and it will be my last question sir. 

Antigens are part of the virus.  Slowing down viral (or antigen) production would NOT effect the test or test results.  As Dr. Handsfield has already informed you, there is NO suggestion that antidepressants IN ANY WAY make tests for HIV less reliable.  

The authors are mis-using the word "significant", something that occurs rather commonly in the less stringent journals I mention above.

This concludes this thread.  It will be closed and ANY new questions on this topic will be deleted without a response.  EWH