[Question #4622] Follow up on [Question #4243] Single act 16 years ago

29 months ago
Hi Dr. 

One thing i forgot to cover off was this.

As this was a 2nd generation test detects IgG antibodies, which from my very limited knowledge are memory type of antibodies. As the potential exposure was around 16 years ago, you would'nt expect any issues from the test detecting these from a potential exposure that long ago would you? In your experience do these antibodies remain detectable throughout the course of the infection from say 3 months onwards to late stage Aids?

I did 2 tests and both came back negative.

Thank you
29 months ago
Meant to add how common is seroreversion when the body cant produce anymore antibodies (if i have that right?)
Edward W. Hook M.D.
Edward W. Hook M.D.
29 months ago
I see that this is your 4th return to the Forum over the past two month and that the previous three responses from Dr. Handsfield and me have been totally in agreement that there is no evidence that you acquired HIV from your single contact over 15 years ago and now, with negative tests (twice!) you have absolutely proven that you were infected.  Yet you continue to circle back with repetitive, "what if" questions, some of which suggest to me that you are spending additional time on the internet regarding your concerns.  Please stay off the internet.  Much of what is there is out of date, taken out of context or just plan wrong.  

Brief answers to your questions:  As Dr. Handsfield has already indicated, when a person acquired HIV they produce antibodies which are detectable by virtually all currently available test. These antibodies remain present for the duration of the infected person's life. They do not go away (this is not a matter of "my experience" this is a repeatedly proven fact).  Seroreversion does not occur with the exception of severely ill, end-stage infection in persons with profound malnutrition.  Getting too the punch line, put your doubts aside- your tests have provided reliable and conclusive results- you did not acquire HIV from the encounter you described.  

I hope these comments will allow you to move forward. EWH
---
29 months ago
Thank you Doc. I know I've overreacted with this and I need to move on and I thank you for your guidance. 

I'm sure it's typo in the response in regards to two tests taken. I'm sure you meant to state I've absolutely proven I wasn't infected.

Just out of interest seroreversion seems to be very rare if it happens at all as it doesn't seem to be a lot written on topic?

Look forward to your thoughts on this and you can consider this closed after this if you wish.

Again thanks 
Edward W. Hook M.D.
Edward W. Hook M.D.
29 months ago
My apologies- you are correct, that was a typo- you have PRVEN that you were NOT infected.  

Issues of seroconversion are a great example of the sort of internet-based misinformation that I referred to above.  EWH
---
29 months ago
No worries. Thanks for yours and Dr HHH help. Don't take this the wrong way but hopefully I don't have to write to you again! :)

Take care 
29 months ago
Apologies last question I promise!!! 

if seroreversion occurs at all at this severely end stage is it fair to assume it's quite rare?

Thanks and take care. 
Edward W. Hook M.D.
Edward W. Hook M.D.
29 months ago
Yes, VERY rare and only in persons who are profoundly ill.

It is now time for us to close this thread.  We both need to be moving on.  EWH
---