[Question #4825] STD

25 months ago
Dear doctors,

I have done the hiv combo test + p24 at several times up to 43 days and it was negative. I also did the pcr rna hiv 1 and hiv2 at day 41 and it was negative. I am going to do hiv combo at days 46 and 49 because some website called  smartsexresource wrote that it is 1% false negative at day 50. I don’t know if that is true. 
Now that this is conclusive; I have weight loss, and swollen glands. Can it be any other std? What do you advice to check? Also to say that I have been feeling really really anxious and I wake up multiple times during my sleep. Can it be that my stress for hiv is causing the weight loss? I lost around 5 kgs in 2 weeks. 
Please advice 
Thank you
Edward W. Hook M.D.
Edward W. Hook M.D.
25 months ago
Welcome to our Forum.  I'll try to help.  when performed at the appropriate time, tests for HIV are among the most reliable tests in all of medicine.  HIV PCR tests are almost always within two weeks of an exposure and combination HIV antigen/antibody tests are conclusive any time more than 6 weeks (42 days) after an exposure.  The on-line source you mention is incorrect.  While you do not say anything about the exposure you are concerned about, my advice is to accept your multiple negative tests which prove that you did not acquire HIV and move forward.  Further testing is a waste of time and money.

Weight loss and swollen glands are highly non-specific problems and few STIs cause such findings.  I would suggest that you look for another reason for your symptoms.  EWH
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25 months ago
Dear doctor 
I was having sex with a girl and condom broke and she had her period. I continued to have sex but I ejaculated outside of her. Anyway long story short 2 weeks after the incident I took her for an hiv combo test and she was negative. “But I keep having anxiety that maybe she has sex with someone a week before me who was positive.”
Anyway I had a few PCRs at day 15,30,41
And I had many combos done from day 21,24,28,33,38,41,43. Day 33 and 41 at two different labs. 

I just want to move on with my life. The girl travelled; if she were here I would have tested her for pcr instead of combo. 
At day 46 I will do my final test at 2 different labs as well. 

So this is my story. Your advice please...
25 months ago
And this is the website
I’m not sure of the accuracy of this
Edward W. Hook M.D.
Edward W. Hook M.D.
25 months ago
As I said before the website you describe is incorrect and, out of date.  you'll please note that the most recent they cite if over 4 years old from publication date.

Further, now the you describe the circumstances of your exposure, I am all the more sure that you should not be worried about HIV.  Most women do not have HIV and your partner had a negative test.  Even if she had HIV (which again, you showed was not the case) there is a more than 99% chance that you would not catch HIV from a single exposure.  You clearly did not get HIV from the exposure you are concerned about.  To continue to worry about it makes no scientific sense whatsoever and prevents you from working with your doctor to find out what is really going on.  As AI said before, continued testing related to this exposure is a waste of time and money.  EWH
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25 months ago
1) if she tested negative.  Will she be able to pass the virus if she had it. 
2) she had her period which is worrying me. 

Edward W. Hook M.D.
Edward W. Hook M.D.
25 months ago
Sigh.  Repeating your question with additional "what if" possible details is not going to change my answers.  Einstein said the one definition of insanity is to keep asking the same questions and expect different answers.  My answers are not going to change.

1.  Persons who do not have HIV do not transmit infection.  There is no evidence that she had HIV and good reason to believe that she did not.  No matter what her history, it had gotten her to the point in life of having sex with you without having a provable HIV infection.
2.  Sex during menses does not change the risk for HIV

This is my third response to your questions. Thus as per Forum guidelines, the thread will now be closed.  I should also point out to you that, as a matter of policy, repetitive, anxiety-driven questions may be deleted without a response and without return of the posting fee.  You really need to move on.  If you cannot, my suggestion is NOT more testing but to seek counseling to help you move past your unwarranted continuing concerns.  EWH
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25 months ago
Does hiv 2 have the same window period in hiv combo test + p24?
Edward W. Hook M.D.
Edward W. Hook M.D.
25 months ago
HIV-2 antibodies have the same time window as HIV-1.  The p-24 antigen test of combination tests detects only HIV-1 p-24 antigen.

End of thread.  EWH
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