[Question #5002] HSV 1&2 IGG test results reliability
78 months ago
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I have had several STD blood tests conducted after an encounter in 2016, several weeks and months after the fact. All negative results. I continue to fear I may be an asymptomatic for herpes 1 or 2. I just took another IGG type specific test 1/3/2019)for both and i continue to be negative <0.90 for both. From everything i have read, this is a very accurate test especially after 6 months post exposure. So am I then negative in your opinion? It has been over two years post exposure. The reason I continue to be concerned, is my wife over the course of the last year has had 4 outbreaks of what appear to be herpes lesions on the corner of her mouth/lip. She has not been tested. We are open with each other and she knows that i have tested, and she has an appointment to speak to her physician about this next month. So if i test negative IGG after this long after the exposure, am I absolutely HSV free both now and in the past? Thank You
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Terri Warren, RN, Nurse Practitioner
78 months ago
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The IgG test, compared to the gold standard western blot, misses 30% of HSV 1 infections and 8% of HSV 2 infections. I wish I could tell you the test is as good as it says it is but our research study looked at the accuracy of the test in a population of people who are requesting screening for HSV 2, not people who already have had a positive swab test, which is how the companies marketing the tests, come up with sensitivity of the test. Here is the reference for this study:
Sexually Transmitted Disease. 2017 Dec;44(12):763-767. Performance of Commercial Enzyme-Linked Immunoassays for Diagnosis of Herpes Simplex Virus-1 and Herpes Simplex Virus-2 Infection in a Clinical Setting.
I wish I could give you more reassurance about your negative status but these are the numbers.
Terri
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78 months ago
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Thank you. So the western blot is the only definitive way I can find out for sure whether I am asymptotic with HSV, correct? Also from what I read it is only performed at Uof W, so do you have information on how I would go about having this test, or if I would even qualify to have it done. Thanks for your time.
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Terri Warren, RN, Nurse Practitioner
78 months ago
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You can work with your own health care provider to obtain this test from UW or I can work with you to obtain it. You can call UW for the kit you need to get the test, 206-685-6066, and then you will need a clinician to order the test and you'll need to have your blood drawn and shipped. If you want me to work with you, you'll need to have an evisit with me. You can sign up for this at westoverheights.com. Or you can certainly work with your regular clinician - the direction in the kit are clear. Remember that the odds are definitely in your favor here of negatives.
Terri
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