[Question #5077] Syphillis testing

25 months ago
Hi I had posted last night and labeled my question “confused” I was not able to log back in for my last follow up question so I had to purchase a new one. I think I may have given the wrong email.  Anyways if someone can please read the question dr hook has stated the prozone phenomenon would not apply to me and only apply to people who have had syphillis for a year or two or decades but that was my question. I have had 7 partners since 2006 and was not always protected so I’m guessing if I got it from one of those partners in the past why would the prozone phenomenon part not apply to me then if I had it for such a long time? I don’t think I have symptoms although I know symptoms are not reliable anyways which is why I ask. I’m just trying to gain some clarity because I am pregnant and very worried maybe something didn’t show up in the rpr and is there another measure I can take. As I said I took two rpr one in first and third trimester and am due soon and reading they could be false negative is worrying me.  Thank you 
H. Hunter Handsfield, MD
H. Hunter Handsfield, MD
25 months ago
As Dr. Hook said in your other thread, you are misunderstanding or over-interpreting informtion you have found on the web about prozone. Most important is that all labs are aware of the prozone problem, and routinely take steps to avoid it. Negative syphilis blood test results are completely reliable. In addition, most labs no longer do RPR as the first test for syphilis. You probably were tested with the newer EIA tests, for which prodrome is not an issue.

For sure you don't have syphilis. Stop worrying about it.

HHH, MD
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25 months ago
Thank you for responding. I am sure it was  called the rpr test because that’s what it says in my paper rpr non reactive. I ordered it on request a test.com and got the blood drawn at a place called lab Corp and got results the next day. If you don’t mind me asking how does the test work and what steps do they take to eliminate prozone? Thank you 
H. Hunter Handsfield, MD
H. Hunter Handsfield, MD
25 months ago
RPR is the ONLY syphilis test subejct to the prozone phenomenon. Prozone is rare, mostly a thing of the past, so even your RPRs are valid. But if you insist on having yet another test, prozone for sure won't be a problem.

You're obviously obsessed by the prozone phenomenon. If you still can't shake your worries about it, please discuss it with your doctor. This is abnormal htinking and potentially a sign of future serious mental health disability. I suggest it from compassion, not criticism.

You are permitted one more follow-up comment on this thread. Do not use it until and unless you have another syphilis blood test to report. After that, any additional new questions from you on this topic will receive no reply and the posting fee will not be refunded. OK?
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