[Question #5182] 4th Gen Hiv test post PEP

24 months ago
Hi Dr,
I have unprotected vaginal intercourse on early Jan this year and put on PEP after 55 hours post exposure. On 74 days post exposure, i have experienced the light headedness as exactly the same during my PEP course. I am worried, and could the light headedness be the ars symptom? Prior to 12 weeks post exposure marks, due to my anxiousness, I have taken 4th gen ELIA hiv test (ag/ab) & RNA PCR (203 copies lower detection limit) on 77 days post exposure (45 days post pep), ELIA hiv test 79 post exposure. All the results are negative. Could it be conclusive enough that i have no HIV infection? Please helpppp. It has been 10th days the lightheadness still with me.
Edward W. Hook M.D.
Edward W. Hook M.D.
24 months ago
Welcome to the Forum.  I'll be glad to try to help, commenting primarily on your laboratory tests but also pointing out that when persons have symptoms due to HIV, particularly recently acquired HIV, both RNA PCR tests and 4th generation tests are typically positive.  Your results at 45 days following completion of PEP are negative and thus are reliable.  The indicate that your symptoms are not due to HIV and that there is no evidence that you acquired HIV from the exposure that you describe.  

There are many causes of lightheadedness and lightheadedness is not a typical symptom of HIV.   My suggestion at this time would be to work with your own doctor to look for other reas0ons for your lightheadedness,   

I hope this information and comment is helpful.  EWH
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24 months ago
Since I have taken the Rna Pcr test on 45 days post pep. Is the result sufficient to conclude me that I don't not have hiv infection? 
Edward W. Hook M.D.
Edward W. Hook M.D.
24 months ago
Yes.  No need for further testing.  EWH---
24 months ago
Have you experienced any patient that sero-converted after 12 weeks post exposure (7 weeks post PEP)? I have read online that PEP might delay the sero-conversion. If so, how high is the possibility for that to happen?
Could the RNA PCR test & 4th gen ELISA test 7 weeks post PEP conclusive enough to prove me that i have really cleared from the HIV infection?
Please help. I really want to move on with my life but these questions been bothering me since after the silly exposure.
Edward W. Hook M.D.
Edward W. Hook M.D.
24 months ago
This question is a bit repetitive.  Conclusive means conclusive!

I have never seen  a person sero-convert following negative tests at more than 6 weeks following completion of PEP.  You fall into this category.  that is why I said " Your results at 45 days following completion of PEP are negative and thus are reliable.  The indicate that your symptoms are not due to HIV and that there is no evidence that you acquired HIV from the exposure that you describe. "  That is ALSO why I said "No need for further testing."

Time for you to move on with your life.

This ends this thread.  As per Forum Guidelines this thread will be closed shortly without further replies.  EWH
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