[Question #5247] 4th generation duo test

76 months ago

I would like to know how accurate CMIA duo is 3 months after exposure and is there any reason to get tested using Nat PCR test. Thank you

H. Hunter Handsfield, MD

76 months ago

Welcome to the forum. Thanks for your confidence in our services.

All the HIV antigen-antibody (duo, combo, 4th generation) blood tests are conclusive about 6 weeks after the last possible exposure, even though some conservative information sources still say 3 months. In any case, there are no known false negative results at 3 months. Assuming you're talking about a negative result, it is conclusive and for sure you do not have HIV unless possibly if you were exposed more recently.

I hope these comments are helpful. Let me know if anything isn't clear.

HHH, MD

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76 months ago

I have read online that some people never produce detectable antibodies, is that true and would it be smart to use viral load test?

H. Hunter Handsfield, MD

76 months ago

First, that's an urban myth; if it actually happens, it is exceedingly rare. But even if antibody were not produced, the whole point of the AgAb (duo tests) is that they test for the virus itself (the antigen part). If antibody isn't produced, the antigen component of the test would be even more strongly positive than otherwise. That's why the AgAb tests are a significant improvement over previous HIV blood tests.---

76 months ago

So what your saying is one or the other would be reactive on the test. What if you had weak immune system would it still find the antigens of the virus. Is this test almost 100% at 3 months.

H. Hunter Handsfield, MD

76 months ago

You're overthinking it. A "weak immune system" in theory could mean reduced antibody production, but that would make the virus MORE detectable. This test is 100% at 6 weeks and therefore also at 3 months.

That concludes the two follow-up comments and replies included with each question and so ends this thread. Please do not be tempted to ask anything more in a new thread: no matter what additional information or circumstances that come to mind, they will not change anything. Move on and stop worrying about it. If you have a regular partner you are concerned about, you can safely have unprotected sex without risk.

I hope the discussion has been helpful. Best wishes.

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