[Question #5271] Recurring False Positive?

23 months ago
I am a 31 year old male.  I did the STI battery during my physical in February 2017 and it showed positive for HSV-2 with an index of 1.2 (IgG) which the doctors keep saying is an "old infection".  I was crushed until I did some research and found out it may have been a false positive.  I then took the Western Blot in April and it came back negative.  I skipped the test last year because I didn't want to go through the emotional roller coaster again.  I took the test again this year and it came back again positive at 1.21 IgG, but this time there was an "HSV-2 IgG Supplemental Test" that was ordered through LabCorp and it came back "Negative".  So I am led to believe this is another false positive, but doubts constantly stay in my mind about which result to believe.

Is this likely another false positive? If so, will this be a recurring result going forward?  And if I keep testing in the low range around that index, will I need to keep going through the hassle and expense of getting a WB each time?

Thank you.

Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
23 months ago
Yes, this is almost certainly a false positive.  And this will happen likely each time you test with the IgG test.  I don't think you do need a blot each time, no.  There is some small risk that this is a real positive, but in your situation, I believe that if you actually became infected, you would have a far higher index value.  And with a negative supplemental test, I believe it even more strongly.

Terri
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