[Question #5723] Hiv 4th gen accuracy is

19 months ago
I’m starting a new relationship and we want to make sure we are safe, so here is the question. My girlfriend got tested with a Hiv 4th gen duo test at 5 weeks post exposure from a single unprotected sexual intercourse with a male.  For all practical purposes, can we move believing  these results or how accurate are they really.  I’ve read 6 weeks conclusive and 4 weeks conclusive.  What is your take Dr.?  
H. Hunter Handsfield, MD
H. Hunter Handsfield, MD
19 months ago
Welcome back. Presumably this is the same new relationship described in your recent discussion with Dr. Hook.

Six weeks is conclusive for the AgAb (antigen-antibody, duo, 4th generation) HIV blood tests. We used to advise 4 weeks, until about 1.5 yr ago, when a comprehensive review showed that on rare occations it took those extra two weeks. However, the difference between and 6 weeks is trivial, and you can consider 5 weeks conclusive, especially given the low chance your partner has HIV (assuming the same person described in your other thread).

I hope these comments are helpful. Let me know if anything isn't clear.

HHH, MD
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19 months ago
It’s actually a new relationship with a new person and we are just wanting to be open and safe and start everything off right.
 Thank you for your reply Dr. 
H. Hunter Handsfield, MD
H. Hunter Handsfield, MD
19 months ago
OK. If she is a typical single woman in the US, the chance she has HIV is no more than one in a thousand. So if you assume "only" 99% certainty for her negative test at 5 weeks, the chance she has HIV is in the range 1 in 100,000. Low enough to be considered zero, in my opinion. Putting it in personal terms, if I were still in dating mode and were in your situation, I would not feel a need for her to have another HIV test. ---
19 months ago
We were just wanting to ensure we can be safe with having unprotected sex without concerns for HIV.  We are both a little OCD
H. Hunter Handsfield, MD
H. Hunter Handsfield, MD
19 months ago
It was pretty obvious, from both threads, that you have more than "a little" OCD! I responded accordingly:  OCD or not, I would consider it conclusive at this point that she doesn't have HIV. But of course it's fine with me if you and she decide to delay sex for another test in a week.

That concludes the two follow-up comments and replies included with each thread. Best wishes for a mutually rewarding and romantic relationship.
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