[Question #5748] Should myself and a new partner get HSV iGG testing?
19 months ago
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19 months ago
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Terri Warren, RN, Nurse Practitioner
19 months ago
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19 months ago
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“I think the other way clinicians can deal with the low positive HSV serology results is to make confirmatory testing reflexive; if you order an ELISA and the result is a 1.1 to 3.5 you reflex it to a Western Blot. I think it should be reflexed to a Western Blot, but having said that I will add the answer isn’t always clear. We might get a 2.8 on an ELISA and then get an indeterminate Western Blot, for example, which isn’t really rare. There isn’t a perfect solution but reflexive testing is a reasonable approach. Sometimes we don’t get a clear answer for people. They can have an indeterminate Western Blot for years and a low positive ELISA with no symptoms, so we really don’t always know if people have herpes or not and that drives them nuts…and I don’t blame them.”
Based on the above quote, is the Western Blot reliable enough to do confirmation ? What percentage of low positives result in indeterminate? Wouldn’t the same protein that tripped the ELISA also trip the Western Blot a majority of the time ?
19 months ago
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19 months ago
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![]() |
Terri Warren, RN, Nurse Practitioner
19 months ago
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