[Question #5766] Negative Blood Test on suppression therapy
72 months ago
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I believe I was exposed to HSV2 in early July 2018. I had a breakout that looked like HSV a few days after (very rough) sex (3-4 lesions appeared, blistered, scabbed over and healed in a week or so). I was unable to get a swab test, but showed pictures to a Doctor (who focuses on HSV) who said it "looks like a classic case". I got on Valtrex almost immediately and wanted to be on suppression therapy to minimize risk to my partner. I took a IGG blood test at 12 weeks that came back negative. I retested at 20 weeks and it came back negative and again at 6 months and it was negative. I was worried that the Valtrex was impacting seroconversion so I reduced the frequency - but didn't completely stop, e.g., I would go a week or two without it and then start to take if I was going to be sexually active). I did have a lesion that showed up in March...not as bad as the initial episode, but I noticed it after my boxer shorts had been rubbing on me wrong followed by some rougher sex. I started taking Valtrex again to be safe, and by the time the dr. could see me for a swab test it was already dried up and scabbed over. I retested in March and now retested in July. All tests have come back negative. So since my (believed) exposure to HSV in early July 2018, I've been negative on 5 tests with the last test being a full 12 months post exposure. Is it likely that I actually don't have HSV? How likely is it that the valtrex has prevented me from seroconverting even after a year? I've read and understand that suppresive therapy can slow the conversion...but won't prevent conversion. But would it slow it to a point of still being negative after a year? I'd been 100% convinced I was positive after the initial breakout but I'm now questioning it. That being said, I want to protect my current partner as much as possible (and have told her I would), so I'm apprehensive about fully stopping the Valtrex. What if I took supressive therapy for another year and was still neg
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Terri Warren, RN, Nurse Practitioner
72 months ago
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I think it is VERY possible that the Valtrex is preventing you from seroconverting. In order to know for sure, you are going to have to fully stop the drug, and take it only with outbreaks and ONLY after you have had any skin changes that are worrisome, swab tested. I have seen someone go a full year without seroconverting, we pulled them off suppression and they were positive at the three month draw. If you are negative at the 3 month draw, then you are unlikely to be infected but your presentation as described is classic, yup.
Terri
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