[Question #5794] Steroids and HIV testing

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72 months ago
Hey Doctor,

I’ll keep this brief. I had a low risk event 108 days ago. I tested at 6 weeks negative, 10 weeks negative and 15 weeks negative using the FINGER PRICK RAPID 4th generation test. But, after the 10 week test, I was given a 120mg injection of Medrol, followed by 84 of medrol taken over a 6 day period for an allergic rash. I waited until 108 to take my final test, which was negative. Would such a dosage of steroids cause a false negative test 36 days after they had been taken? I also have been using a steroid cream for 4-5 days at the time of 108 day test. Are my result conclusive? Or will I need to wait longer? Thank you! 
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Edward W. Hook M.D.
72 months ago
Welcome to our Forum.  I'll be glad to comment.  Currently available tests for HIV are amongst the most reliable tests in all of medicine.  Further because the 4th generation tests test not only for antibodies which theoretically (but in real life rarely) could slow antibody appearance, ALSO test for the virus (this is what the p24 antigen test looks for) which, if a person were not producing antibody, would be resent in higher than average concentrations (because there would be no antibody present to fight the virus).  In your case, your tests at 6 weeks and 10 weeks were conclusive before you received the steroids, as were subsequent tests.  You can be entirely confident of your test results.  Further testing would be a waste of time and resources.  

I hope that this information is helpful to you.  EWH
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72 months ago
Thank you so much Dr. Hook, so to be clear, if my test at 108 days using the 4th Gen Finger Prick (does this matter?) had been the only test I took, given the 200mg of steroids taken over the course of a week, 36 days earlier from the test date + the steroid cream I have used for five days at the time of the test, I can still trust my test to be 100% conclusive and have unprotected sex with my main partner without fear of infecting her?
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Edward W. Hook M.D.
72 months ago
"To be clear", your tests at six and ten weeks were DEFINITVE.  Subsequent testing is IRRELEVANT.  Thus, while there is a theoretical concern that IF you had been exposed in the period between your 10 week test and the 108 (15+week) day test, that antibodies might not be produced but with the p24 antigen as part of the test, your results should be considered definitive.  You need to accept your test results, not ask "what if" questions.  EWH---
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72 months ago
Thank you very much. You can close this thread 
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Edward W. Hook M.D.
72 months ago
Thank you.  Glad I could help.  EWH---