[Question #5853] Follow up to Question #5472 Elisa Positive WB Negative at 5 weeks.
72 months ago
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Hi,
I am back with regards to my previous question 5472.
Some updates on testing done, i had an elisa positive and WB negative test at 5 weeks and have followed up with a hiv -1 rna and proviral dna pcr (qualitative) test at 7.5 weeks, which have also turned up negative. I took that as an end to the issue. I asked for hiv-2 but my doctor was saying there is really no need for it since exposure in Singapore is extremely rare if not none. Is this conclusive enough from the risk i had exposed myself to back in #5472?
However, now 4 months on from the incident, i did a full body check and the elisa have turned up positive again, pending a WB test now. In between the 4 months, i haven't had any new instances of exposure so what do i make of this? Do people test repeatedly positive on Elisa once they have tested false positive once? My doctor was telling me this is the case for many people but i am thrown right back into a panic and anxious state.
Is this a case of delayed seroconversion? I felt some lymph nodes but my doctor is saying they are not abnormally enlarged to be of worry but at this point, i am really lost.
Your comments are very much appreciated and important to me. Thanks.
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Edward W. Hook M.D.
72 months ago
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Welcome back to the Forum. I'll be glad to comment. Having had a falsely positive ELISA test for HIV, it is likely that you will continue to have falsely positive tests when tested using the same sort of test. Falsely positive tests arise when your body produces antibodies that happen to cross react with the targets of the ELISA test and those antibodies are more likely than not to be there for the rest of your life. Thus, on repeat testing it is no surprise that your test was once again positive.
Delayed seroconversion is a myth perpetuated on the internet which does not exist.
I agree with your doctor's assessment. This is not something to worry about. I hope my reassurance, along with his/hers will be helpful to you. EWH
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72 months ago
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Hi Dr Hook,
Thanks once again for your kind reply. It means alot to see this reply from you.
Is the hiv -1 rna and proviral dna pcr (qualitative) test at 7.5 weeks close to conclusive that i do not have HIV as i have read? or is there a chance it might be wrong and it is a false negative?
Also, revisiting my exposure, was it a no risk exposure and i shouldnt have gotten tested?
Thank you once again!
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Edward W. Hook M.D.
72 months ago
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I'll answer your 2nd question first. Both of the exposures you describe in your two early posts were no risk events for which there was no need for testing. If you had asked me whether you should have been tested or not, I would have said no.
Yes, if your HIV PCR tests were negative at 7.5 weeks the results were definitive and there in no need for further testing, particularly in your specific situation when there was no risk for infection to begin with.
Hope this helps. EWH
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71 months ago
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Hi Dr Hook,
My results are back and it came out exactly as what you have said. Another false Elisa positive, WB negative. At this point, my doctor is saying definitively that i do not have HIV since the test is 4 months after exposure and it is some other antibodies causing cross reactivity.
I have also done an extensive body screen for autoimmune diseases because i read it can cause reactivity with Elisa tests, all these came back negative. I have healthy Hep B antibodies which shows i am immune. The only thing that flags out is a positive IgG test for Lyme, which i am waiting on a WB confirmation. Are there any other significant tests that i should run if the WB for Lyme comes back negative?
I am hoping to conclusively put the whole issue to bed.
Thanks in advance!
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Edward W. Hook M.D.
71 months ago
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Thanks for your follow-up. While persons with autoimmune illnesses tend to have a somewhat higher rate of false positive tests on many different types of tests, most persons with false positive tests are just unlucky and do not have obvious problems with autoimmune illness. The false positive rate for Lyme disease is much, much higher than the FP rate for HIV. My sincere advice going forward is to be aware that you have the false positive tendency on some tests for HIV and then stop worrying a go forward. I see no reason for further testing unless there is a specific problem that you are investigating.
I hope this information has been helpful to you. As you know we provide up to three responses to each client's question and thus this thread will soon be closed without further responses. Take care. Please don't worry. EWH
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