[Question #5880] HSV2 help!!

20 months ago
Husband Had unprotected oral sex receiver and giver and protected vaginal sex. One incident. Tested positive for chlamydia 7 days post exposure, which I’m noting because due to that positive result I took the antibiotics as well. Within 3 days of the antibiotics (and 9 days post exposure to my husband. We had sex a few times when he would have been 5 days post exposure) I developed a yeast infection? At 23 days post exposure for myself and 28 days post exposure for him we retested and did a full health screen. The results of the hsv igg are confusing. I tested positive for HSV1. Not surprised and negative for HSV2. He tested negative for HSV1 and positive for HSV2. His levels were 1.35  I need clarification on 1. Is this a yeast infection? If I’m taking the treatment it seems better but never goes away. It has been 2.5 weeks. If I let up with the treatment it comes back. Symptoms come and go with 2 particular areas of concern inside my vagina. 2 red areas that are sore. But ironically not at the same time. No blisters or raised skin. Just more red then the other areas. Burning tingling itching all over. Could this be an outbreak? (A note...took another dose of flucanazole and the symptoms seem to have gone away for now) I also did a pcr swab which was negative. I have noticed a little bit of a burning.  
 sensation on my upper inner thighs. But I’m not sure if I’m nowbjust being paranoid.  And 2. With levels that low could this be an older infection for him? No symptoms. Looking back he says over the years he has noticed little things like little tears or perhaps a small pimple here and there. Nothing currently at 40 days post exposure. we also did an IGM test out of curiosity on day 31. His level was 1.8.   We live in the UK. Is the western blot available outside of the US? I hope that all makes some sort of sense. Thanks for your time.
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
20 months ago
I'm not sure where this answer went - but I will repeat.
This is very likely a false positive result.  The CDC suggests that anyone with this level of positive index value (1.1 to 3.5) obtain a confirmatory test, the best is the western blot.  I know this isn't available where you but samples can easily be shipped to the US lab IF you can find someone to draw and spin one serum separator tube of blood.  I think it would be worth you trying or you will always wonder if he has herpes or not and likely act on that.  What do you think?

Terri
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20 months ago
Hi Terri. We spoke on your other forum as well. That’s may be why you remember. I have further information and don’t know what to do. 

Husband has had another IGG done. 6 weeks post exposure and 17 days from the previous IGG. First IGG was 1.35 second was 1.26 He had been prescribed antivirals as described above and had been taking them for 3-4 days at the time of the blood draw for IGG. So my questions now are 

1. Is it a good thing that the numbers haven’t increased at all, what could that mean, and am I correct in my understanding that the antivirals wouldn’t have had an effect on the IGG test at that point? 

2. Should he continue taking the antivirals if he wants to to the western blot?

3. Can you help us obtain the western blot through you, even if we are in the UK? Thanks again.


Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
20 months ago
It is a good thing that his numbers didn't go up BUT taking antivirals can mess with test results and if he wants the blot, he should certainly consider stopping them.  How long has he taken them?
I definitely can help you but you will need to identify someone who will draw and spin one serum separator tube of blood.  Let's have you do that first and then we can talk about the logistics of the test, OK?  We can get it done for sure if you can do that part.

Terri
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20 months ago
Thank you again! He has been taking them for about 10 days. At the time of the last blood draw he had been taking them 3-4 days. I was under the impression that less than 2 weeks would have no impact on index values? Perhaps that’s my mistake. He will stop taking them now so we can accurately have the western blot performed. 

I will now look to find a lab here to help me obtain the sample. Thank you. 
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
20 months ago
I think 10 days should have no impact on antibody development IF he waits the appropriate 12 weeks from the encounter to get the blot.

Terri
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