[Question #6003] HSV Test Results
71 months ago
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Hello. Thank you for taking the time to review and answer my questions.
Approximately one year ago my 7 yr old daughter was hospitalized with a severe case of what turned out to be HSV 1 (Oral). Subsequently, I noticed sores on my lips that were similar to the early stages of the sores that my daughter had on her lips - although mine never turn into blisters like hers do. I had a swab done of the sores on my lips and the HSV results came back negative. I had my daughter's similar sores swabbed and the result for the HSV and her results came back negative too.
Because my daughter had a confirmed case of HSV 1, and I had sores on my lips similar to hers, my doctor prescribed to me an antiviral for treatment of the suspected HSV 1 outbreak. However, despite daily doses of the prescription for 6 months, my lips sores persist. Similarly, my daughter has to take daily antiviral to manage her symptoms, if she stops she'll have a full outbreak (blisters on lips).
At the request of my doctor, I had a blood draw for HSV 1 & 2. The HSV Type 1/2 DNA PCR (whole blood) test came back negative. However, the HSV 1 IgG Type Specific AB test came back as positive with a score of 42.10, the HSV2 IgG Type Specific AB test was negative.
Questions:
1) Would a daily antiviral result in a false negative for the HSV Type 1/2 DNA PCR?
2) Would a daily antiviral result in a false positive for the HSV 1 IgG Type Specific AB test?
3) What does it mean that the HSV 1 IgG Type Specific AB test value is so high (42.10)?
4) I've been told that the HSV Type 1/2 DNA PCR test is the gold standard for HSV testing and can be used on different body fluids, including a blood draw. IS that correct?
5) Given the conflicting results, which one is accurate?
Thanks!
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Terri Warren, RN, Nurse Practitioner
71 months ago
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71 months ago
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![]() |
Terri Warren, RN, Nurse Practitioner
71 months ago
|