[Question #6039] Negative for chlamydia and gonorreah?

19 months ago
Hello, I am probably being paranoid. I am female. I had unprotected vaginal sex one time a month ago. My partner pulled out before ejaculating.  Just as a precaution I was screened for chlamydia and gonorreah about one month after sex. My tests were negative. At the time I tested, I had been taking 500 mg amoxicillin for a bladder infection...I had taken 1 1/2 days worth...so about 7 pills. Could this have caused a false negative? I spoke to my partner, and he had not had sex for 6 months or so prior to our encounter, and he has never had any symptoms...I believe him, but just need reassurance that my test was accurate. Thank you!
H. Hunter Handsfield, MD
H. Hunter Handsfield, MD
19 months ago
Welcome to the forum. Thanks for your confidence in our services.

Amoxicillin is active against most but not all strains of gonorrhea, and also has modest activity against chlamydia. Although not recommended for routine treatment of either of these STDs, it occasionally is used successfully to treat chlamydia in patients who cannot tolderate first-line regimens. The important thing to know in this situation is that antibiotics do not cause false negative results or otherwise make test results unreliable. Your negative result reliably shows you do not have either infection. If you had either one, it has been cured by the amoxicillin. In other words, the only way amoxicillin would make your test result negative is to cure the infection. If somehow it merely suppressed gonorrhea or chlamydia without curing it, your test would have been positive.

Accordingly, your test results are reliable -- you can be sure you do not have either infection, even if there was a very slight chance you were infected and then cured. And in any case, it sounds very unlikely your partner was infected anyway. So all is well -- no worries!

I hope this response has been helpful and reassuring. Let me know if anything isn't clear.

HHH, MD
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19 months ago
Thank you very much! I appreciate you all providing this forum. 
H. Hunter Handsfield, MD
H. Hunter Handsfield, MD
19 months ago
Thanks for the thanks. Music to my ears -- that's why we're here!---