[Question #6075] Testing HIV

17 months ago
Hi Dr,

If a person tests negative on an HIV RNA Test at 14 days post exposure and negative on a DUO 4th generation test at 28 days post exposure, is this conclusive or do you have to take another at 42 days. Just trying to figure out window periods. I appreciate your service.

Thanks
H. Hunter Handsfield, MD
H. Hunter Handsfield, MD
17 months ago
Welcome back but sorry you found it necessary, given the reassuring reply and other comments by Dr. Hook in your two recent threads.

By itself, the AgAb (duo) test is conclusvie at 6 weeks and the RNA test nearly so at 2 weeks. The combination of results you had, with negative RNA at 2 weeks and AgAb test at 4 weeks is 100% conclusive. No moe testing is needed.

HHH, MD

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17 months ago
Thanks Dr, I have not had the DUO yet as its only been 24 days. I’ll have it on Tuesday which is 28 days. I’m having severe anxiety and am glad I won’t have to wait 42 days. It seems the DUO used to be conclusive at 28 days, just confused 
H. Hunter Handsfield, MD
H. Hunter Handsfield, MD
17 months ago
Thanks for the thanks. Stay mellow while you wait:  there is no realistic chance you have HIV. You might like to know that in the 15 years I and Dr. Hook have been doing this and a previous forum, with thousands of questions about HIV risk or testing after an anxiety-producing exposure, not one has ever reported a positive HIV test. You won't be the first! When that happens, I'm confident it will be a truly high risk exposure, like unprotected sex with a known infected person. Try not to worry about it.---
17 months ago
Last question, then I will leave you alone forever. Why would the combo of tests be 100 percent conclusive? Is it because most people would test positive at 14 days on RNA and most people at 28 days on fourth generation? Thanks for the kind words, more appreciated than you know
H. Hunter Handsfield, MD
H. Hunter Handsfield, MD
17 months ago
With those results, you will have had two tests for the virus itself (HIV RNA and p24 antigen) plus an antibody test, showing the body's immune response to the virus. Thre may abe a theoretical possibility of someone being negative on all those at 2 and 4 weeks, but the odds are higher you'll be hit by a meteorite. There has never been a reported case of sometone with such test results who turned out to have HIV, except maybe a few people taking anti-HIV drugs for post-exposure prophyaxis that doesn't work.

Really, stop worrying about this. Accept the reasoned, science based reassurance you have had.

That completes the two follow-up comments and replies included with each questiona nd so ends this thread. I hope the disucssion has been helpful.
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