[Question #6139] Misdiagnosis?

16 months ago
Approximately two to two and a half years ago I had sex with an HSV 2 positive woman. Two to three weeks after, I had a blood test done and came back with a result of 5.3. I no longer have the results, and cannot determine if it was IGG or IGM. This week, I was tested with IGG in response to an outbreak, only my second in the entire time I've had herpes, by an infectious disease specialist. It was negative for both HSV 1 and 2. He did a visual exam and said it was negative. He believes it to be some kind of skin irritation. Regardless, I am confused. I've been on suppression therapy since my initial diagnosis...could this have affected the test? Do I have herpes or not?
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
16 months ago
Well, a visual exam at any given time has zero meaning but a negative IgG test does have meaning.  compared to the gold standard herpes western blot, the IgG test picks up 92% of HSV 2 infections.  In terms of the antiviral suppression, it normally impact test results only when when one takes it with brand new infection, but a 5.3 index value would indicate a not new infection.  But 5.3 is quite a high value to just go to nothing.  I think if it were me, I would stop the suppression (you chances of transmission will increase if you are having sex with an uninfected person) and get a western blot 3 months later.  You situation is truly confusing.

Terri
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