Hi Dr. I read many posts on this website before posting my question.i see that 4them ge. Ab/ag test conclusive at 6 weeks and RNA at 3 weeks. With no PEP irrespective of type of exposure 

I meant to say, can my negative test results with 4th gen and RNA be 100% conclusive at 20 weeks 

Welcome to our Forum.  I'll try to help.  You are "bargaining" here.  HIV RNA PCR tests are almost always positive at 11-12 days following an exposure.  Over 99% of 4th generation tests are positive at 4 weeks (28 days) and are completely conclusive at 6 weeks.  A combination of a negative PCR test and a negative 4th generation test at 20 days is almost certainly not going to change with additional time but there are no data to inform the answer.

Further, you apparently do not want to describe your exposure but the fact is, that too matters. 

Let's not play game.  Get a grip on yourself! Personally, with both tests negative at 20 days would give me great reassurance and I would not feel a need for further testing BUT, if you want to know if there is scientific evidence that these results would be absolutely conclusive, then the answer is no.

I hope this comment is helpful.  EWH

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Hi Dr Hook. I think you misread my question, the exposure was 20 weeks ago not 20 days. 

Thanks for the clarification, I did misread your question.  Negative tests at 20 weeks are absolutely conclusive.  No need for concern or for additional testing of any sort.  Again, sorry for the error in reading your question.  EWH
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Thanks dr and one last question and I will stop.

Your follow-up question, as I read it is repetitive and does not change my answer.  Current 4th generation tests for HIV are amongst the most reliable tests in all of medicine.  They are conclusive for all persons who have not received anti-HIV therapy at all times more than 6 months after an exposure.  The statement that they are conclusive is based on the evidence provided by many studies evaluating virtually tens of thousands of persons using different tests which agree, validating each other.  For instance in your case, your two tests have looked for evidence of HIV in three different ways- by looking for viral RNA (the PCR test), by looking for viral proteins (the p24 antigen) and by looking for antibodies to HIV.  Believe your test results.  No further testing is warranted for any encounter which occurred more than 20 weeks ago.  EWH
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Thanks Dr. I believe you meant 6 weeks in your answer and not 6 months. 

You are correct- 6 weeks.  Typing too fast

I have now replied three times to your questions and comments.  As per Forum Guidelines, this thread will be closed shortly. EWH

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