[Question #6255] HIV RNA test accuracy

18 months ago
Hi doctors, can you please explain what is the HIV RNA qualitative labcorp test accuracy on 14th day after exposure. I ordered the test from stdcheck.com, on their website it says that it detects infection from 9 to 11 days and I read many posts here and you mentioned that 4th gen test is conclusive at and after 6 weeks and combination of RNA and 4th gen are conclusive at and after 4 weeks. Did you come across or heard anyone turn positive after a negative RNA at 14 days. My exposure was handjob and blowjob from a high risk exposure girl and I don't know her status.
Edward W. Hook M.D.
Edward W. Hook M.D.
18 months ago

Welcome to our Forum.  I'll try to help, starting with letting you that there are NO proven cases in which anyone has acquired HIV as a result of either participating in masturbation of any kind, nor from receipt of oral sex.  If you had asked if you needed testing, I would have said no.

Regarding test performance, there is the "official" recommendation and my own experience which differ slightly.  All involved agree that virtually all persons who have acquired HIV will have positive HIV RNA PCR tests by 11 days after an exposure.  Perhaps out of an abundance of caution however, official recommendations are that a negative PCR taken before 4 weeks should be followed by a 4th generation test for conformation at some point around 4 weeks or beyond.  In my own experience, in the literature, and at meetings I attend, I have never seen or heard of someone with a negative PCR test at 11 days or beyond who went on to become positive.

In your own case, given the no risk nature of your exposure I would urge you to believe a PCR test if it was taken after more than 11 days and to more forward without concern and without the need for further testing related to the exposure you are concerned about.  I hope this information is helpful,.  EWH

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18 months ago
Thanks for the help Dr. I just got the RNA result and it was negative. I took on Wednesday, was my 14th day. I just started developing sore throat could be a coincidence and because of weather change
Edward W. Hook M.D.
Edward W. Hook M.D.
18 months ago
This would certainly be a coincidence.  I urge you to believe your test results.EWH---
18 months ago
Thank you for the assurance dr. Am sorry to ask you again. Do you think I can go ahead resume my sexual activities with my normal partner or would it be better and safe to wait another 4weeks and get a 4th gen test? Sorry for repeatin
18 months ago
Hi Dr, just changing again to see what's your suggestion is on my above question please 
Edward W. Hook M.D.
Edward W. Hook M.D.
18 months ago

Sorry for missing your earlier follow-up question.  Our site had server "issues" which has impact response times/

Indeed, your question is repetitive an asking the question again will, in no way, change my assessment or response.  I would have no hesitancy to have unprotected sex with your regular partner if I were you. 

As you know, this is my final response as art of this thread.  As per Forum Guidelines, this thread will be closed shortly without further responses..   I hope that the information provided has been helpful.  EWH

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